Prediction of Delayed Toxic Cardiomyopathy in Children (SpeckleAnthra2)
Cardiotoxicity, Childhood Cancer
About this trial
This is an interventional prevention trial for Cardiotoxicity focused on measuring Echocardiography, Ventricular function, Stroke Volume
Eligibility Criteria
ANTHRA GROUP Inclusion Criteria: Patients who were treated with anthracyclines for malignant disease between the ages of 0 and 18 Patient aged 11 to 27 years Included in the "SpeckleAnthra" Study (NCT02893787) Discontinued chemotherapy for more than 6 years Patient in remission of malignant disease Enrolled in a social security plan Written informed consent from at least one legal representative for the minor patient/ Written informed consent for patients of legal age Exclusion Criteria: Onset of active malignancy or recurrence of malignancy after the "Speckle Anthra" study that required resumption of chemotherapy or mediastinal radiotherapy. Chronic cardiac, pulmonary or muscular pathology of etiology other than secondary to anthracycline therapy For adult patients: subject under guardianship or curators CONTROL GROUP Inclusion Criteria: Control patient included in the "Speckle Control" study (NCT02056925) Had a cardiological consultation with echocardiography performed for a banal reason (heart murmur test, cardiological symptoms) and whose result was normal No chronic disease or long-term drug treatment Exclusion Criteria: Refusal to participate in the study by the patient and/or parents or legal guardian after receipt of the study's information and non-objection note.
Sites / Locations
- Pediatric and Congenital Cardiology and Pulmonology Department, Arnaud De Villeneuve University HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Anthra2
Control
Patient will have an echocardiography with speckle tracking analysis 5 years after the end of their participation to "SpeckleAnthra" study (NCT02893787)
Cardiac ultrasound analysis with speckle tracking of age- and sex-matched healthy patients in the Anthra2 group