Dexmedetomidine for Intermittent Epidural Boluses Versus Continuous Epidural Infusion for Labour Epidural Analgesia
Labor Pain
About this trial
This is an interventional prevention trial for Labor Pain
Eligibility Criteria
Inclusion Criteria: Age 18 - 45 years Scheduled for normal vaginal delivery ASA physical status ӀI-IӀӀ. Singleton non-complicated pregnancy. At least 36 weak of gestation. Vertex presentation. Exclusion Criteria: Patient refusal to epidural analgesia. History of cardiac, liver, or kidney diseases. History of allergy to amide local anesthetics or study medications. Any neurological problem. History of chronic opioid analgesic use. Any contraindication of regional anesthesia. Evidence of intrauterine growth restriction or fetal compromise. Failed or unsatisfactory analgesic block. Body mass index ≥40 kg/m2
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Group P (PIEB-group)
Group C (CEI-group)
After the initial epidural loading dose of 10 ml, 30 patients will receive programmed intermittent epidural boluses (5 ml every 45 min with the first bolus 30 minutes after epidural initiation) + patient controlled epidural analgesia (PCEA) as 5 ml boluses with a 20-minute lockout period).
After the initial epidural loading dose of 10 ml, 30 patients will receive continuous epidural infusion (5 ml/h starting immediately after the loading dose) + patient controlled epidural analgesia (PCEA) as 5 ml boluses with a 20-minute lockout period).