Dietary Supplementation With Blueberry in OA
Knee Osteoarthritis
About this trial
This is an interventional treatment trial for Knee Osteoarthritis
Eligibility Criteria
Inclusion Criteria: Participants capable of giving informed consent Sex: Male and female Age: > 40 years - Those under 40 are more likely to have an undiagnosed secondary cause of osteoarthritis BMI: > 18 kg/m2 Listed to have a total knee replacement for osteoarthritis Participants are permitted to participate in other ongoing surgical intervention studies, as long as these are not trials of a dietary supplement or a medication. Exclusion Criteria: Those who have received intravenous or oral immunosuppressant medications in past 2 years Those who have had intra-articular steroid injection in 6 months preceding surgery. Some secondary causes of osteoarthritis (mechanistic confounders that are likely to influence tissue inflammation measures: Known congenital joint disorders Other inflammatory arthritis e.g. rheumatoid arthritis Avascular necrosis, infectious arthritis Paget disease Osteopetrosis Osteochondritis dissecans Hemochromatosis Wilson's disease Hemoglobinopathy Ehlers-Danlos syndrome Marfan syndrome Acromegaly Those typically consuming more than eight 80 g portions (or juice equivalent) of blueberries, blackberries, strawberries, raspberries, blackcurrants, pomegranate or cherries per week Those with a known fruit allergy, for which they carry an adrenaline auto-injector or have required anti-histamine, adrenaline, glucocorticoid or beta-agonist treatment. Those who cannot adequately understand verbal explanations or written information given in English
Sites / Locations
- Royal Devon University HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Placebo Comparator
Experimental
Placebo
Blueberry Supplementation