Precision Exercise to Improve Outcomes in Sepsis (PRECISE)
Sepsis
About this trial
This is an interventional other trial for Sepsis focused on measuring Sepsis, Exercise Tolerance, Exercise Training
Eligibility Criteria
Inclusion Criteria: Signed informed consent At least 19 years of age ≥60 days prior to study enrollment, known or suspected infection that includes at least two of the following clinical criteria that together constitute a new bedside clinical score termed quickSOFA (qSOFA): respiratory rate >22breaths/min, altered mentation, or systolic blood pressure <100mmHg. Cardiorespiratory fitness <80% of age and sex-predicted norms Can commit to attending 3 exercise sessions a week for 12-weeks Exclusion Criteria: Unable to provide informed consent On supplemental oxygen Known previous cardiac or cerebral vascular events in the past 90 days Diabetes Autoimmune diseases or on daily immunomodulatory drugs Obstructive sleep apnea Uncontrolled hypertension Known pregnancy/ intending to get pregnant within 28 days of enrolling in the study or breastfeeding Desaturation during exercise SpO2<85% Cardiovascular contraindication or musculoskeletal limitations to exercise as assessed during the cardiopulmonary exercise test
Sites / Locations
- St. Paul's Hospital - Centre for Heart Lung InnovationRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
Exercise Intervention
Attention Control
Patients will participate in a 12-week (36 sessions) precision exercise training intervention
Patients will not receive exercise training but will be contacted 1x per week via phone to document self-reported physical activity and general wellbeing.