Acute Effects of Focused Ultrasound Modulation on EEG Behavior in Status Epilepticus Patients
Seizures
About this trial
This is an interventional treatment trial for Seizures
Eligibility Criteria
Inclusion Criteria: Subjects diagnosed with ongoing NCSE or FMSE despite treatment with at least 2 ASMs Provision of signed and dated informed consent form obtained from the next-of-kin/legally authorized representative Treated in the ICU while monitored with continuous scalp EEG electrodes Exclusion Criteria: Unable to obtain informed consent Presence of an implanted cranial neuromodulation device for treatment of epilepsy Pregnancy Treatment with another investigational drug or other intervention within 24 hr Presence of burr hole(s) or craniotomy Subjects with ferromagnetic materials in the head Subjects with a TENS unit
Sites / Locations
- Yale New Haven HospitalRecruiting
Arms of the Study
Arm 1
Experimental
Participants with ongoing non-convulsive or focal motor SE
Adult patients with ongoing non-convulsive or focal motor SE despite treatment with at least 2 ASMs and who are monitored with surface EEG will be screened and enrolled to receive up to 2 sessions of PLIFU.