Impact of Pycnogenol® on Gingival Inflammation (PINEGIN)
Periodontitis
About this trial
This is an interventional treatment trial for Periodontitis
Eligibility Criteria
Inclusion Criteria: number of teeth ≥ 10 age ≥ 35 ≤ 90 years body mass index (BMI) ≥ 20 ≤ 30 history of periodontal disease and inclusion in a regular scheme of supportive periodontal therapy (regularly repeated subgingival biofilm removal 2-4 x/year) minimum of 10% probing sites displaying bleeding on probing Exclusion Criteria: manifestation of inflammatory oral mucosal diseases other than gingivitis xerostomia (stimulated salivary flow ≤ 0.1 ml/minute) inability to perform regular oral home care inability to follow the study protocol due to intellectual or physical handicaps history of malignancy, radiotherapy, or chemotherapy for malignancy in the past 5 years current pregnancy acute infections such as HIV manifestation of metabolic bone disease use of antibiotics and/or anti-inflammatory medications within 4 weeks prior to screening. current orthodontic therapy
Sites / Locations
- Dept. of Periodontology, Center for Oral HealthRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Placebo Comparator
Pycnogenol Group
Placebo Group
Professional mechanical plaque removal + Pycnogenol capsule
Professional mechanical plaque removal + placebo capsule