Opioid Sparing Analgesia Continuous Intraoperative Infusion of Dexmedetomidine Versus Lidocaine for Laparoscopic Cholecystectomy
Analgesia
About this trial
This is an interventional supportive care trial for Analgesia
Eligibility Criteria
Inclusion Criteria: Patient's status ASA status-I and II. Patients age above 18 years old. Patients scheduled for laparoscopic cholecystectomy. Exclusion Criteria: Patient refusal. Patients with known allergy to dexmedetomidine or lidocaine. Patients with significant hepatic dysfunction. Patients with severe renal disease. Patients with chronic pain. Regular use analgesics, antidepressants or opioids in last month. Any known convulsive disorder. Significant heart disease. Morbid obesity (BMI>35). Patients with autoimmune disease Patients on corticosteroid therapy Pregnancy Breast feeding Woman under hormonal treatment
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Dexmedetomidine group
Lidocaine group
This group will receive continuous intraoperative dexmedetomidine IV infusion [1ug/kg dexmedetomidine over 15 min as a loading dose and 0.5ug/kg/h for maintenance].
This group will receive continuous intraoperative lidocaine IV infusion [1.5 mg/kg lidocaine over 15 min as a loading dose and 1.5 mg/kg/h for maintenance].