High-frequency nrTMS on the Contralateral Broca Mirror Area for Glioma Patients With Early Postoperative Aphasia
Non-fluent Aphasia, Glioma
About this trial
This is an interventional treatment trial for Non-fluent Aphasia focused on measuring human, language recovery, neuronavigated repetitive transcranial magnetic stimulation
Eligibility Criteria
Inclusion Criteria: A. Right-handed, age: 20~65 years old, tumor involves left language function area, no previous history of treatment of neurological diseases, and preoperative cognitive and language function assessment is normal B. Access to formal education at the primary level and above C. Postoperative pathology is primary low-grade glioma D. Language function assessed as motor aphasia on days 7-10 after surgery E. Willing to receive nrTMS rehabilitation F. The patient and family sign informed consent Exclusion Criteria: A. Tumor grows across the midline to the opposite side B. Undergoing unplanned surgery after the first tumor resection C. Patients request to withdraw from the study during treatment D. During the treatment period, the patient is unable to continue treatment due to force majeure E. Patient loss or refusal of follow-up during the study F. Patients are considered by the investigator to be unsuitable for participation in this study
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Experimental
Sham Comparator
nrTMS treatment
nrTMS sham
using nrTMS coli to stimulate the contralateral Broca's area on the right hemisphere with high freqency stimulation.
using nrTMS sham-coli to stimulate the contralateral Broca's area on the right hemisphere with high frequency stimulation.