PROcalcitonin and Presepsin-guided Decision for Antibiotic Prophylaxis of EOS (PROPOSE)
Early-Onset Neonatal Sepsis
About this trial
This is an interventional prevention trial for Early-Onset Neonatal Sepsis focused on measuring Early-Onset Sepsis, Procalcitonin, Presepsin, Preterm infant
Eligibility Criteria
Inclusion Criteria: infants of 25+0- 31+6 weeks of gestational age will be enrolled in the study. Exclusion Criteria: Risk factors for EOS: maternal GBS colonization without adequate prophylaxis; clinical chorioamnionitis diagnosed by maternal intrapartum fever (either a single documented maternal intrapartum temperature of ≥39.0°C or a temperature of 38.0-38.9°C that persists for >30 minutes) and 1 or more of the following: (1) maternal leukocytosis, (2) purulent cervical drainage, and (3) fetal tachycardia; pre-labor rupture of membranes (ROM) >1 h before delivery. Surgery within the first week of life, major congenital malformations, chromosomal syndromes, inherited metabolic disorders, fetal hydrops
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
Antibiotic prophylaxis for EOS
Procalcitonin/Presepsin guided antibiotic prophylaxis for EOS