Ultrasound Treatment on Wound Healing Time (GE-MTEC)
Burn Wound, 2nd Degree Burn of the Skin
About this trial
This is an interventional treatment trial for Burn Wound
Eligibility Criteria
Inclusion Criteria: Male or Female aged 18 or older Second-degree burn wounds of less than 20% total body surface area (TBSA) No active wound infection at screening based on clinical criteria Able to provide written informed consent Exclusion Criteria: Wounds determined by study clinicians to be ineligible, including those that may inhibit access to the spleen for the ultrasound procedure Participating in another research study that may affect the conduct of results of this study BMI > 30 Having or exhibiting any of the following: Previous surgery of the spleen, esophagus, stomach, duodenum, or liver, including splenectomy End stage renal disease and/or uremia Active malignancy Previous leukemia and/or lymphoma Human immunodeficiency virus infection or AIDS Rheumatoid arthritis or other immune-mediated diseases (e.g., inflammatory bowel disease Arrythmias, including but not limited to, atrial fibrillation, atrial flutter, clinically significant bradycardia, ventricular arrhythmias, and A-V block Implanted pacemaker or cardioverter/debribrillator History of unstable angina, angioplasty or coronary arterial by-pass grafting surgery History of stroke or TIA Untreated thrombosis or bleeding disorders Currently implanted vagus nerve stimulator Currently implanted spinal cord stimulator or other chronically implanted electronic device Receiving oral, topical, rectal, or parenteral corticosteroids in an unstable dose 4 weeks prior to baseline visit Any immunosuppressive or cytotoxic medications Clinically relevant history of alcohol or drug abuse as determined by the investigator including: alcohol consumption within 4 days of the baseline visit tobacco or nicotine product use within the past 1 month recreational drug use within the past 1 month Pregnant or breast feeding Unable or unwilling to comply with study procedures Have recently (within 3 months) been diagnosed with COVID, or have ever been diagnosed with long COVID Have an autoimmune disorder, such as, rheumatoid arthritis or lupus
Sites / Locations
- LAC+USC Medical Center
Arms of the Study
Arm 1
Arm 2
Sham Comparator
Active Comparator
LOGIQ E10 Sham
LOGIQ E10 ultrasound Active
The sham condition will consist of the ultrasound probe placed over the spleen with no energy applied.
The intervention condition will receive 10 minutes of splenic ultrasound daily.