Behavioral Treatment and Memantine in Body Focused Repetitive Behaviors
Skin-Picking, Trichotillomania (Hair-Pulling Disorder)
About this trial
This is an interventional treatment trial for Skin-Picking
Eligibility Criteria
Inclusion Criteria: Men and women ages 18+ Current DSM-5 diagnosis of trichotillomania (TTM) or skin picking disorder (SPD) Ability to understand and sign the consent form Stable dose of medications for at least the past 3 months Exclusion Criteria: Unstable medical illness based on history or clinically significant abnormalities on baseline physical examination Current pregnancy or lactation, or inadequate contraception in women of childbearing potential Subjects considered an immediate suicide risk based on the Columbia Suicide Severity rating Scale (C-SSRS) Past 12-month DSM-5 diagnosis of psychosis, bipolar disorder, mania, or a substance or alcohol use disorder Illegal substance use based on urine toxicology screening Previous treatment with memantine Previous trial of ComB or similar BT protocol (e,g., habit reversal training) Cognitive impairment that interferes with the capacity to understand and self-administer medication or provide written informed consent
Sites / Locations
Arms of the Study
Arm 1
Experimental
Memantine and Behavioral Therapy
All subjects will receive 8-weeks of memantine treatment (10mg po qday for the first two weeks, then 20 mg po qday for the remaining six weeks). After the 8-weeks of memantine treatment, the dose will be discontinued. Then, after a 4-week washout period, all subjects will receive 8-weeks of ComB therapy. Therapy will be once a week for 30 minutes. After the 8-weeks of ComB treatment, the therapy will be discontinued.