Effect of NST Whole-course Nutritional Management on Nutritional Status and Adverse Reactions in Esophageal Cancer
Esophageal Neoplasms, Adverse Drug Event
About this trial
This is an interventional supportive care trial for Esophageal Neoplasms
Eligibility Criteria
Inclusion Criteria: Sign the informed consent; must have good compliance with the treatment plan and follow-up. No gender restriction, but age between 18 and 75 years old; Cytological or histological is confirmed esophageal squamous cell carcinoma; Non-surgical treatment of stage II-III primary esophageal cancer (except biopsy); The primary tumor can be evaluated; No distant organ metastasis; PG-SGA score B (2~8) or C (≥9); KPS score ≥ 70 points, ECOG physical condition score 0-1 points; The function of major organs (bone marrow, liver, kidney function) 7 days before treatment, meet the following criteria: Blood routine examination standards (without blood transfusion within 14 days): Hemoglobin (HB) ≥ 100g/L; White blood cells (WBC) ≥ 4×109/L; Absolute neutrophil count (ANC) ≥1.5×109/L; Platelet (PLT) ≥ 100×109/L. The biochemical examination shall meet the following standards: Total bilirubin (TBIL) ≤ 1.5 times the upper limit of normal (ULN); Alanine aminotransferase (ALT) and aspartate aminotransferase AST ≤ 1.5 times ULN; Serum creatinine (Cr) ≤ 1.5 times ULN or creatinine clearance rate (CCr) ≥ 60ml/min. Expected survival ≥ 6 months. Exclusion Criteria: No malnutrition or nutritional risk; PG-SGA score of A; Severely impaired intestinal function, or intolerance of enteral nutrition; Severe vomiting, gastrointestinal bleeding, intestinal obstruction; Patients with very severe malnutrition cannot tolerate radiotherapy and chemotherapy; The primary tumor or lymph node has received radiotherapy, chemotherapy or targeted therapy; Suffering from other malignant tumors within 5 years (except for completely cured cervical carcinoma in situ or skin basal cell carcinoma); Subjects who have received other drug trials within the past month; Those with severe allergic history or idiosyncratic constitution; Those with a history of severe lung or heart disease; Serious comorbidities, such as uncontrolled hypertension, heart failure, etc.; Pregnant or breastfeeding women; Currently or planning to participate in other clinical trials; Refusal or inability to sign the informed consent form to accept participation in the trial.
Sites / Locations
- The First Affiliated Hospital of Nanjing Medical UniversityRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
NST intervenes throughout the process
Routine nutrition guidance group for esophageal cancer
Nutritionists formulate nutritional programs and manage them in a refined manner. The nutritionist urges the patient to report daily to ensure that the patient's energy and protein are in place Radiotherapy chemotherapy
Patients perform their own nutrition regimen, and the nutritionist is not involved in management Radiotherapy chemotherapy