Quetiapine as Prophylaxis for Delirium in CABG
Delirium
About this trial
This is an interventional prevention trial for Delirium
Eligibility Criteria
Inclusion Criteria: Patients aged 65 or older old of age undergoing open heart surgery and having an equal or greater score of 5 on the scale of Delphi. Age: 70-79 years: 1 point; ≥ 80 years: 2 points Physical activity: need for assistance, not self-sufficient: 2 points Alcoholism: 1 point Hearing impaired: 1 point History of delirium: 2 points Emergency of surgery: 2 points No laparoscopic surgery: 2 points Admission critical unites: 3 points Value of C reactive protein (CRP) ≥ 10mg/dl: 1 point Exclusion Criteria: .Patient refusal. Allergy to quetiapine Patients with a score less than 5 on Delphi scale Diagnosis of delirium on admission initial CAM-ICU (the Confusion Assessment Method-ICU) positive) Could not communicate due to previously diagnosed irreversible neurologic disease (stroke, cerebral hemorrhage, traumatic brain injury, dementia, etc.) High risk for ventricular arrhythmias (Corrected QT interval ≥ 460 millisecond in men, ≥ 470 millisecond in women or ongoing treatment with drugs known to prolong the QT interval (e.g., erythromycin, class Ia, Ic, III anti-arrhythmic drugs) Second or third degree heart block High risk for drug interaction with quetiapine (phenytoin, carbamazepine, barbiturates) Electrolyte disturbance : Potassium less than 3 or magnesium less than 1.5 Patient on antipsychotic drug treatment prior to admission Parkinson's disease
Sites / Locations
- Ain shams university hospitalsRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
No Intervention
Group Q
Group C
will receive 25 mg quetiapine at night of surgery and 25 mg daily for 7 days postoperative
will receive placebo alone