Turmeric Gel as Alternative Non-vital Pulpotomy Medicament in Primary Teeth
Non-Vital Tooth
About this trial
This is an interventional treatment trial for Non-Vital Tooth
Eligibility Criteria
Inclusion Criteria: Cooperation of patients and consent of parents. Patients with ASA classification I and II (mild to moderate systemic disease). Non-traumatic extensively carious hence restorable primary molars. No history of antibiotic use for 2 weeks. Presence of following clinical signs or symptoms suggestive of non-vital tooth such as tenderness on percussion, non-responsive to cold test, periapical/furcal radiolucency, localized gingival/mucosal soreness/ redness/ swelling, and/or slight mobility-grade I. Exclusion Criteria: History of allergy to anesthetics and latex. Radiographic evidence of pulpal floor opening into the furcation area. More than half of the roots resorbed.
Sites / Locations
- de' Montmorency College of Dentistry
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
Formocresol (Control-Gold standard-Group A)
Turmeric gel (Experimental-Group B)
Premade Formocresol (Tricresol & Formalin) was used composed of Tricresol 35%, Formaldehyde (40%) 19%, excipient additive 100% (PD, Switzerland, ISO9001/ISO9001_2000/ ISO13485/CE_MARK), (Universal Dental Pvt, Ltd).
Turmeric gel will be self-prepared at the Institute of Microbiology and Molecular Genetics, Punjab University, Lahore. 2kgs of Turmeric rhizomes were purchased from a local market in Lahore and verified by a taxonomist, Botany Department, Government College University, Lahore (voucher number: GC.Herb.Bot.3693). Approximately 170g powder along with 550ml distilled water will be taken in a Soxhlet extractor for 96 hours and then filtered repeatedly through Whatman No.1 filter paper. The obtained filtrate will then be mixed with 6% Sodium Carboxy-Methyl Cellulose (NaCMC) (Genevex Chem, Hyderabad, India) to form gel. Four Vitamin C grounded tablets (Wilson's Vitamin C, Wilson's Healthcare, Islamabad, Pakistan) and twelve Vitamin E capsules (Evion, Martin Dow pharmaceuticals, Ltd. Karachi, Pak) will then be added in 100g of gel as antioxidants.