Treatment Strategy of Vasovagal Syncope (CAMPAIGN)
Syncope, Vasovagal
About this trial
This is an interventional treatment trial for Syncope, Vasovagal focused on measuring Vasovagal syncope, Cardioneuroablation, Midodrine
Eligibility Criteria
Inclusion Criteria: Age ≥ 18 years of age Calgary Syncope Symptom Score ≥ -2 points Positive response to head-up tilt test With syncope episodes more than 3 times in the preceding year Willingness to comply with follow-up requirements and to sign the informed consent Exclusion Criteria: Complied with other causes of syncope, including postural hypotension, aortic stenosis, sick sinus node syndrome, high-grade atrioventricular block, ventricular arrhythmias, pulmonary hypertension, hypertrophic cardiomyopathy, transient ischemic attack, epilepsy, sequelae of cerebral infarction or cerebral hemorrhage, subclavian vein steal syndrome and drug-induced syncope. Complied with congenital heart disease, valvular heart disease, cardiomyopathy, and diabetes. History of cardiac catheter ablation, peacemaker implantation and cardiac surgery. History of midodrine usage, or compiled with contradiction of midodrine, including urine retention, hypertension (Bp≥140/90mmHg), glaucoma, renal dysfunction. NYHA class IV congestive heart failure or LVEF < 35% Pregnancy or breast-feeding Life expectancy <1 year for any medical condition
Sites / Locations
- Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical CollegeRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Experimental group: Cardioneuroablation
Control group: Midodrine
In this arm, the catheter ablation of the GPs will be performed in the order of LSGP, LIGP, RIGP, left atrial RAGP、right atrial RAGP. Patient education includes fully informing patients of the benign prognosis of vasovagal syncope, and educating patients to avoid triggering factors as much as possible. At the same time, the patient should be taught how to cope with the impending syncope with physical counter-pressure maneuvers and dietary suggestions that emphasize fluid and sodium intake.
In this arm, Midodrine will be applied without the following contraindications: hypertension, chromaffin cell carcinoma, acute nephritis, severe renal dysfunction, glaucoma, prostatic hyperplasia with urinary retention, mechanical urinary obstruction, hyperthyroidism. Patient education includes fully informing patients of the benign prognosis of vasovagal syncope, and educating patients to avoid triggering factors as much as possible. At the same time, the patient should be taught how to cope with the impending syncope with physical counter-pressure maneuvers and dietary suggestions that emphasize fluid and sodium intake.