Noninvasive Temporal Interference Stimulation: Modulating Associative Memory by Targeting Deep-brain Targets (Deep-HiPs)
Healthy Aging, Memory Disorders in Old Age, Mild Cognitive Impairment
About this trial
This is an interventional treatment trial for Healthy Aging focused on measuring temporal interference stimulation, associative memory, hippocampus, precuneus, fMRI, EEG
Eligibility Criteria
Inclusion Criteria: Intact cognition with the ability to comprehend the experimental task right-handed Exclusion Criteria: left-handed severe internal disease, cancer brain tumour, intracranial surgery, psychiatric disorder severe neurological brain disease; i.e.: epilepsy, stroke etc. the presence of a pacemaker/defibrillator, metal incompatible with magnetic resonance in the body incapacitating musculoskeletal disorders cognitive impairment based on screening tests severe impairment of vision
Sites / Locations
- CEITEC Masaryk university
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Placebo Comparator
Active TIS of the hippocampus
Active TIS of the precuneus
High-frequency stimulation
Participants will undergo Active TIS of the hippocampus as one of the 3 conditions within the trial in randomized order.
Participants will undergo Active TIS of the precuneus as one of the 3 conditions within the trial in randomized order.
High frequency >1Khz stimulation; Assumption: The intrinsic low-pass filtering of electrical signals by the neural membrane prevents neural electrical activity from following very high-frequency oscillating (e.g., > 1 kHz) electric fields.