HVNI Versus NIV In Management Of Acute Hypercapnic Respiratory Failure In OHS
Obesity Hypoventilation Syndrome (OHS)
About this trial
This is an interventional treatment trial for Obesity Hypoventilation Syndrome (OHS)
Eligibility Criteria
Inclusion Criteria: Age >18 years. Obesity hypoventilation syndrome with acute hypercapnic respiratory failure. A) Body mass index [BMI] ≥ 30 kg/m2. B) Daytime hypercapnia (PaCO2 > 45 mm Hg) C) PH < 7.35 D) Arterial oxygen saturation (SaO2) <90% Exclusion Criteria: Age <18 years. Pulmonary infiltrates suggesting pulmonary edema, pneumonia, active tuberculosis, or its sequelae. Patients with gas exchange alterations due to other conditions, such as bronchiectasis, fibrosis of the pleural space (fibrothorax), neuromuscular disease and chronic obstructive pulmonary disease (COPD) Pregnancy. Contraindications for positive-airway pressure devices.
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
High-Velocity Nasal Insufflation
Non-Invasive ventilation