Furosemide-induced Diuresis With Matched Dehydration Compared to Standard Diuretic Therapy in Patients With Acute Heart Failure and Overt Fluid Overload (MYTHOS-HF)
Acute Decompensated Heart Failure
About this trial
This is an interventional treatment trial for Acute Decompensated Heart Failure
Eligibility Criteria
Inclusion Criteria: >18 years of age New York Heart Association (NYHA) functional class III or IV estimated weight gain due to peripheral fluid overload >4 kg admission BNP values >400 pg/ml if in sinus rhythm and >600 pg/ml if in atrial fibrillation Exclusion Criteria: inability to provide informed consent acute pulmonary edema, cardiogenic shock end-stage renal disease (Stage V) or need for renal replacement therapy ongoing treatment with Entresto (BNP not reliable) need for inotropic/vasopressor drug support contraindications to placement of a Foley catheter. Known hypersensitivity to furosemide
Sites / Locations
- Centro Cardiologico Monzino, IrccsRecruiting
Arms of the Study
Arm 1
Arm 2
No Intervention
Experimental
Control Group
RenalGuard group
Furosemide infusion (standard treatment)
Furosemide infusion with matched de-hydration