Enhancement of Circadian Rhythms in ICU Patients Through Light Intervention

Inclusion Criteria: Patient capable of giving consent or additionally existing legal caregiver or authorized/spouse representative in case of non-consenting patients in the intensive care unit Male and female patients with age ≥ 18 years Expected intensive care unit stay ≥ 5 days Exclusion Criteria: Participation in other clinical studies during the study period and ten days before Previous ICU treatment during the current hospital stay Patients with psychiatric diseases Patients with a history of stroke and known severe residual cognitive deficits Patients with a history of cardiopulmonary arrest or pulseless electric activity with cardiopulmonary resuscitation followed by therapeutic hypothermia during entire hospital stay Analphabetism Anacusis or Hypoacusis with hearing aid device, Amaurosis Accommodation in an institution due to an official or judicial order History of sleep-related breathing disorders History or suspicion of hypoxic brain damage History or suspicion of elevated intracranial pressure in the last 7 days before study inclusion Patients with an open chest after cardiac surgery Patient has a power of attorney or patient's provision, where he/she refuses participation in any clinical trial The informed consent of the patient or the subject's legally acceptable representative can't be obtained in time History of photoallergic reactions or history of visually triggered seizures Severe eye diseases (e.g. retinopathy, glaucoma) or high sensitivity to bright light Patients with liver cirrhosis Patients with a probability of survival <24h