Fluorescence Imaging With Indocyanine Green(ICG) in Endoscopic Spinal Surgery
Disc Herniation
About this trial
This is an interventional diagnostic trial for Disc Herniation focused on measuring Disc Herniation, Endoscopy, Indocyanine green, Near-infrared fluorescence imaging, Spinal nerve roots
Eligibility Criteria
Inclusion Criteria: Patients diagnosed with lumbar disc herniation based on symptoms and Imaging examination Patients undergo endoscopy spinal surgery for nerve root decompression Patients have no clear contraindications to surgery, and has the ability to understand and act and has informed consent, and can participate in all study follow-up voluntarily and signe a written informed consent form. Exclusion Criteria: The patients have thyroid related diseases, including autonomous nodules Patients are allergic to iodine or shellfish Patients have ankylosing spondylitis, lumbar instability or bony spinal stenosis Patients have diabetes, vascular related diseases, or abnormal liver and kidney function Difficulty in tolerating anaesthesia Pregnant or lactating women Patients are unable to communicate or do not follow directions The investigators consider the patient unsuitable to participate in this study
Sites / Locations
- Department of Spine Surgery and Musculoskeletal Tumor, Zhongnan Hospital of Wuhan UniversityRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
No Intervention
Experimental
Experimental
Experimental
Control group
0.5mg/kg ICG group
1mg/kg ICG group
2mg/kg ICG group
Standard endoscopic spinal surgery
The patients receive 0.5mg/kg ICG intravenous injection before surgery. The search for lumbar nerve roots is performed with the assistance of fluoroscopic endoscopic imaging equipment. And the procedure follows standard endoscopic spinal surgery procedures.
The patients receive 1mg/kg ICG intravenous injection before surgery. The search for lumbar nerve roots is performed with the assistance of fluoroscopic endoscopic imaging equipment. And the procedure follows standard endoscopic spinal surgery procedures.
The patients receive 2mg/kg ICG intravenous injection before surgery. The search for lumbar nerve roots is performed with the assistance of fluoroscopic endoscopic imaging equipment. And the procedure follows standard endoscopic spinal surgery procedures.