Accelerated High-dose Sequential Bilateral Theta Burst Stimulation for Treatment Resistant Depression
Treatment Resistant Depression
About this trial
This is an interventional treatment trial for Treatment Resistant Depression
Eligibility Criteria
Inclusion Criteria: Diagnosis of MDD (DSM-V) Adults in the age range of 18 - 65 Both sex HAMD-17 score of ≥20 TRD - failure to two antidepressant trial Stage II (Thase and Rush classification) Exclusion Criteria: Post traumatic stress disorder, Obsessive compulsive disorder, Psychosis Bipolar disorder, substance abuse disorder, autistic spectrum disorder, active suicidal behavior Epilepsy Dementia, Movement disorders severe head injury Brain metallic implants, cardiac pacemakers Pregnancy . Non-response to prior rTMS, Electroconvulsive treatment, Vagal nerve or Deep brain stimulation or a history of psychosurgery. Borderline personality disorder, Schizotypal, schizoid & paranoid personality disorder Current treatment with anticonvulsants or benzodiazepines
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Experimental
Sham Comparator
Active stimulation
Sham stimulation
Bilateral real TBS
Bilateral Sham stimulation