Fenofibrate Role in Breast Cancer Patients
Breast Cancer
About this trial
This is an interventional treatment trial for Breast Cancer
Eligibility Criteria
Inclusion criteria: included a diagnosis breast cancer with age > 18 years. Naïve to chemotherapy Exclusion Criteria: Concurrent administration (statins , cyclosporine) . Advanced liver disease (defined as liver enzyme elevation >3-fold upper limit of normality, or cirrhosis); chronic kidney disease (CKD, defined as an eGFR <60 ml min-1 1.73 m-2); acute or chronic pancreatitis and diabetes. Patients with a history of allergy to fenofibrate. Concomitant use of opioids, anticonvulsants, tricyclic antidepressants, other neuropathic pain medication. Pregnancy or breast feeding.
Sites / Locations
- Damanhour Oncology CenterRecruiting
Arms of the Study
Arm 1
Arm 2
Placebo Comparator
Active Comparator
Placebo Group
fenofibrate group
n=25: will receive Placebo plus four cycle of AC followed by paclitaxel 80 mg/m2 weekly for 12 week.
n=25: will receive fenofibrate 160mg once daily for 3 month plus four cycle of AC followed by paclitaxel 80 mg/m2 weekly for 12 week. .