Association of Apical Periodontitis With Systemic Level of Inflammatory Markers : A Longitudinal Intervention Study
Diabetes Mellitus, Type 2, Apical Periodontitis
About this trial
This is an interventional treatment trial for Diabetes Mellitus, Type 2 focused on measuring Apical Periodontitis, Diabetes mellitus, High sensitivity C-reactive protein, Tumor necrosis factor-alpha, Interleukin, Glycated hemoglobin
Eligibility Criteria
Inclusion Criteria: Patients 30-55 year age group with minimum 20 natural teeth, with pulp necrosis confirmed by cold test and electric pulp test and radiographic evidence of periapical radiolucency with PAI score of ≥3 (24) or more in at least one mature tooth. control in the systemically healthy group will be selected to match participants in terms of age, sex, and BMI. control for participants with type 2 DM will be selected to additionally match with glycaemic control, drugs and dietary measures apart from other physical attributes. Exclusion Criteria: Patients with clinical diagnosis of moderate to severe periodontitis (≥6 sites with probing depth ≥5 mm at separate teeth, with attachment loss and radiographic alveolar bone loss), Patients with immunosuppression, pregnancy, conditions requiring prophylactic antibiotics prior to dental treatment, bleeding disorders, medical conditions that may affect study participation (e.g., unstable cardiovascular disease) and chronic inflammatory conditions like rheumatoid
Sites / Locations
- PGIDSRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Active Comparator
Active Comparator
Diabetic patients with Apical periodontitis
Healthy patients with Apical periodontitis
Diabetic patients with out Apical periodontitis
Healthy participants without Apical periodontitis
Diabetic patients with Apical periodontitis received Endodontics treatment in form of Root canal treatment and assessment of inflammatory and metabolic markers
systemically healthy participants patients with Apical periodontitis received Endodontics treatment in the form of root canal treatment and assessment of inflammatory markers
systemic inflammatory markers along with metabolic markers will be assessed
systemic inflammatory markers will be assessed