"Physiological vs Right Ventricular Pacing Outcome Trial Evaluated for bradyCardia Treatment" (PROTECT-HF) (PROTECT-HF)
Bradycardia, Pacing, Right Ventricular Pacing
About this trial
This is an interventional treatment trial for Bradycardia
Eligibility Criteria
We will recruit patients who are referred for clinically indicated pacemaker implantation Inclusion Criteria: 1. Adults aged over 18 with left ventricular ejection fraction >35% and one or more of the following guideline based ventricular pacing indications: Permanent or intermittent 3rd degree AV block Permanent or intermittent Mobitz type II AV block First Degree AV block with a pacing indication Slow chronic Atrial Fibrillation or Proposed AV node ablation Bifasciular block with a pacing indication Trifasicular block with a pacing indication Wenckebach with a pacing indication Exclusion Criteria: Patients who are likely to only need occasional ventricular pacing, i.e. those with isolated sick sinus syndrome. Pregnant women. Unable to provide informed consent. Those with comorbidity leading to a life expectancy <1year.
Sites / Locations
- Hammersmith HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
Right ventricular pacing
Physiological pacing
Right ventricular pacing (apical or septal lead locations as per the implanting physicians' normal practice)
The approach for physiological pacing will be either His bundle pacing or left bundle pacing at the operator's discretion. If both of these are not achieved biventricular pacing will be performed.