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Improvement of Personalized Lung Cancer Care Through Digital Connection and Patient Participation (DigiNet) (DigiNet)

Primary Purpose

Non-small Cell Lung Cancer Stage IV

Status
Recruiting
Phase
Not Applicable
Locations
Germany
Study Type
Interventional
Intervention
DigiNet intervention
Sponsored by
University of Cologne
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Non-small Cell Lung Cancer Stage IV focused on measuring Carcinoma, Non-Small-Cell Lung, Carcinoma, Non-Small-Cell Lung* / diagnosis, Carcinoma, Non-Small-Cell Lung* / genetics, Precision Medicine, Pathology, Molecular, Patient Reported Outcome Measures, Database Management Systems

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria: Patients diagnosed with advanced NSCLC, stage IV Age > 18 years Life expectancy at least 4 weeks (initial assessment at inclusion in nNGM and confirmation at baseline (implementation of treatment decision)) Exclusion Criteria: Missing informed consent Illnesses and behaviors that impair compliance (e.g., dementia, addictive disorders) Severely impaired general physical condition that no longer permits therapy for lung cancer

Sites / Locations

  • Hämatologisch-Onkologische SchwerpunktpraxisRecruiting
  • Johanniter-Krankenhaus BonnRecruiting
  • Universitätsklinikum Bonn (UKB)Recruiting
  • Zentrum für ambulante Hämatologie und Onkologie Rhein-Sieg (ZAHO)Recruiting
  • Klinikum Dortmund GmbHRecruiting
  • Gemeinschaftspraxis für Hämatologie & OnkologieRecruiting
  • Universitätsklinikum Düsseldorf (UKD)Recruiting
  • Universitätsklinikum EssenRecruiting
  • Onkologische GemeinschaftspraxisRecruiting
  • Praxis für Hämatologie und Internistische OnkologieRecruiting
  • MV-Zentrum für Hämatologie und OnkologieRecruiting
  • Universitätsklinikum KölnRecruiting
  • MVZ West GmbH Standort Köln-KalkRecruiting
  • Praxis Internistischer Onkologie und Hämatologie (pioh)Recruiting
  • Klinikum LeverkusenRecruiting
  • Märkische Kliniken GmbH, Klinikum LüdenscheidRecruiting
  • Kliniken Maria Hilf GmbHRecruiting
  • MVZ für Hämatologie und OnkologieRecruiting
  • Praxis und Tagesklinik für Internistische Onkologie und HämatologieRecruiting
  • Krankenhaus Bethanien SolingenRecruiting
  • Onkologie RheinsiegRecruiting
  • MVZ Medizinisches Versorgungszentrum am Marien-Hospital WeselRecruiting
  • Medizinisches Versorgungzentrum am Evangelischen Krankenhaus Wesel GmbHRecruiting
  • Onkologie ErzgebirgeRecruiting
  • Hämatologisch Onkologisches Centrum Ostsachsen ONCOS GmbHRecruiting
  • Fachkrankenhaus CoswigRecruiting
  • Onkozentrum Dresden/Freiberg/MeißenRecruiting
  • Gemeinschaftspraxis Dr. med. Johannes Mohm Dr. med. Gabriele Prange-KrexRecruiting
  • Gemeinschaftspraxis Hämatologie - OnkologieRecruiting
  • Universitätsklinikum Carl Gustav Carus DresdenRecruiting
  • Ev. Diakonissenkrankenhaus LeipzigRecruiting
  • Ambulante Onkologie OstsachsenRecruiting
  • Helios Klinikum ErfurtRecruiting
  • Alexianer St. Hedwig Kliniken Berlin GmbHRecruiting
  • Charité Universitätsmedizin BerlinRecruiting
  • Onkologische Schwerpunktpraxis TiergartenRecruiting
  • Onkologische Schwerpunktpraxis KurfürstendammRecruiting
  • Praxis am VolksparkRecruiting
  • Vivantes Klinikum NeuköllnRecruiting
  • Evangelische Lungenklinik BerlinRecruiting
  • Onkologie SeestraßeRecruiting
  • DRK Kliniken Berlin MitteRecruiting
  • Lungenarztpraxis TegelRecruiting
  • Gemeinschaftskrankenhaus HavelhöheRecruiting
  • Helios Klinikum Emil von BehringRecruiting
  • Onkologischer Schwerpunkt am Oskar-Helene-HeimRecruiting

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

No Intervention

Arm Label

DigiNet group

Comparison group

Arm Description

The intervention group will receive the DigiNet intervention.

The comparison group will receive usual care.

Outcomes

Primary Outcome Measures

Overall Survival (OS)
Overall Survival (OS) will be assessed in months.

Secondary Outcome Measures

Progression-Free Survival (PFS)
Progression-Free Survival (PFS) will be assessed in months.
Time on First Treatment (ToT)
Duration under first-line therapy will be assessed in months.
Hospitalization rate
Frequency of hospital stays will be assessed using health insurance data.
Quality of Life (EORTC QLQ-C30)
Quality of Life (European Organisation for Research and Treatment of Cancer, Quality of Life Core Questionnaire, EORTC QLQ-C30) will be assessed in absolute values and change over time. Each item is rated on a response scale 1 = "not at all" to 4 = "very much" with exception of the last two items, which assess overall health and quality of life on a scale from 1 = "very poor" to 7 = "excellent". All EORTC QLQ-C30 scale scores range from 0 to 100, whereby higher scores on a functional scale indicate a high level of functioning, whereas higher scores on a symptom scale/symptom item indicate greater symptom burden.
Quality of Life (EORTC QLQ-LC29)
Quality of Life (European Organisation for Research and Treatment of Cancer, Quality of Life Questionnaire Lung Cancer, EORTC QLQ-LC29) will be assessed in absolute values and change over time. Each item is rated on a response scale 1 = "not at all" to 4 = "very much" and refer to the time frame "during the past week". All EORTC QLQ-LC29 scale scores range from 0 to 100, whereby higher scores for a symptom scale/symptom item indicate greater symptom burden.
Symptoms of anxiety (GAD-2)
Symptoms of anxiety (Generalized Anxiety Disorder Scale-2, GAD-2) will be assessed in absolute values and change over time. Each item is rated on a response scale 0 = "not at all" to 3 = "nearly every day" and refer to the time frame "during the past two weeks". Higher scores indicate greater symptom burden.
Symptoms of depression (PHQ-2)
Symptoms of depression (Patient-Health-Questionnaire-2, PHQ-2) will be assessed in absolute values and change over time. Each item is rated on a response scale 0 = "not at all" to 3 = "nearly every day" and refer to the time frame "during the past two weeks". Higher scores indicate greater symptom burden.
Frequency of applied targeted molecular therapies based on clinical therapy information from the MURIEL database
The frequency of applied targeted molecular therapies is based on clinical therapy information from the MURIEL database.
Frequency of active contact of the expert advisory board with physicians during the course of treatment
Assessing the frequency of the expert advisory board actively contacting physicians during the course of treatment
Completeness of the documentation of the treatment course
Assessing the completeness of the documentation of the treatment course (DigiNet study visits) in %.
Frequency of patients' completing the PROs
Assessing the frequency of patients' completing the patient-reported outcomes (PRO) via the internet portal
Cost-effectiveness of DigiNet compared to standard care in terms of incremental costs per life years gained
Assessing the cost-effectiveness of DigiNet compared to standard care in terms of incremental costs per life years gained
Cost-effectiveness of DigiNet compared to standard care in terms of costs per quality-adjusted life year [QALY]
Assessing the cost-effectiveness of DigiNet compared to standard care in terms of costs per quality-adjusted life year [QALY]
Cost of implementation related to DigiNet from the service provider perspective (hospital, practices)
Assessing the cost of implementation related to DigiNet from the service provider perspective (hospital, practices) in Euro (€)
Process costs related to DigiNet from the service provider perspective (hospital, practices)
Assessing the process costs related to DigiNet from the service provider perspective (hospital, practices) in Euro (€)
Formative evaluation
Formative evaluation regarding the implementation will be conducted using qualitative analysis of semi-structured interviews

Full Information

First Posted
December 12, 2022
Last Updated
August 8, 2023
Sponsor
University of Cologne
Collaborators
Gemeinsamer Bundesausschuss (G-BA), AOK Rheinland/Hamburg, AOK Nordwest, BARMER, University Hospital, Essen, Charite University, Berlin, Germany, Berlin Institute of Health, Helios Klinikum Emil von Behring, University Hospital Carl Gustav Carus, Deutsche Krebsgesellschaft e.V., Berufsverband der Niedergelassenen Hämatologen und Onkologen in Deutschland e.V., AOK Bundesverband, FOM Hochschule für Oekonomie und Management, University Medicine Greifswald, Technische Universität Dresden
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1. Study Identification

Unique Protocol Identification Number
NCT05818449
Brief Title
Improvement of Personalized Lung Cancer Care Through Digital Connection and Patient Participation (DigiNet)
Acronym
DigiNet
Official Title
Improvement of Personalized Cancer Care for Patients With Advanced Non-Small Cell Lung Cancer (NSCLC) Through Digital Connection of Specialized Cancer Centers, Community Hospitals, Private Practices and Patients (DigiNet)
Study Type
Interventional

2. Study Status

Record Verification Date
August 2023
Overall Recruitment Status
Recruiting
Study Start Date
June 1, 2022 (Actual)
Primary Completion Date
March 31, 2025 (Anticipated)
Study Completion Date
March 31, 2025 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
University of Cologne
Collaborators
Gemeinsamer Bundesausschuss (G-BA), AOK Rheinland/Hamburg, AOK Nordwest, BARMER, University Hospital, Essen, Charite University, Berlin, Germany, Berlin Institute of Health, Helios Klinikum Emil von Behring, University Hospital Carl Gustav Carus, Deutsche Krebsgesellschaft e.V., Berufsverband der Niedergelassenen Hämatologen und Onkologen in Deutschland e.V., AOK Bundesverband, FOM Hochschule für Oekonomie und Management, University Medicine Greifswald, Technische Universität Dresden

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No

5. Study Description

Brief Summary
The aim of the DigiNet project is to improve the treatment of patients with advanced non-small cell lung cancer (NSCLC) in Germany. The project promotes the transfer of the latest scientific knowledge into standard care. The DigiNet project is based on the established precision medicine program, the National Network Genomic Medicine Lung Cancer (nNGM) in Germany, whereby every patient receives molecular diagnostics and personalized therapy information after the initial diagnosis. Within the framework of the DigiNet project, specialized academic centers will be digitally connected with practitioners via a shared project database. Furthermore, a committee of experts will monitor the course of treatment and will advise the practitioners in case of critical conditions. Additionally, patient-reported outcomes will be incorporated into the treatment.
Detailed Description
The aim of the DigiNet project is to prospectively evaluate a precision medicine program for lung cancer and to improve personalized care of patients with advanced non-small cell lung cancer (NSCLC) through a collaboration of specialized academic centers with routine care providers (hospitals, oncology practices). The use of targeted therapies will be regularly monitored and guided through a shared digital database. Patients with an initial diagnosis of stage IV NSCLC in the study regions (study region east: Berlin and Saxony; study region west: North Rhine-Westphalia) are included. DigiNet builds on the foundations and structures of the National Network Genomic Medicine Lung Cancer (nNGM) in Germany, which provides molecular diagnostics and treatment information to the participating physicians based on the latest evidence. Within the framework of DigiNet, patients are regularly consulted by the study practitioners and the clinical data is documented in a structured manner in a central project database. Through the digital collaboration of the nNGM network centers via the shared project database with the practitioners in routine care, continuous monitoring of the course of treatment and, in the case of critical conditions, treatment guidance by an expert committee advising the practitioner is provided. In addition, the patients routinely assess the quality of life (EORTC QLQ-C30, EORTC QLQ-LC29, EQ-5D), as well as anxiety and depression (PHQ-4). The results of these patient-reported outcomes (PROs) are incorporated into the treatment by the practitioners (patient-centered treatment approach). The evaluation of the project is structured into different core domains: An evaluation of clinical endpoints, process parameters (implementation of the intervention), and health economic evaluations will be conducted. The acceptance and potential for improvement of the project will be assessed through qualitative interviews with the stakeholders. Data from the state cancer registries of the study regions will be incorporated to generate a population-based comparative cohort for the evaluation of the main research questions of DigiNet, thereby representing patients receiving routine care in Germany.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Non-small Cell Lung Cancer Stage IV
Keywords
Carcinoma, Non-Small-Cell Lung, Carcinoma, Non-Small-Cell Lung* / diagnosis, Carcinoma, Non-Small-Cell Lung* / genetics, Precision Medicine, Pathology, Molecular, Patient Reported Outcome Measures, Database Management Systems

7. Study Design

Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Non-Randomized
Enrollment
2400 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
DigiNet group
Arm Type
Experimental
Arm Description
The intervention group will receive the DigiNet intervention.
Arm Title
Comparison group
Arm Type
No Intervention
Arm Description
The comparison group will receive usual care.
Intervention Type
Other
Intervention Name(s)
DigiNet intervention
Intervention Description
Patients with initial diagnosis of NSCLC stage IV in the model region receiving the following interventions: broad NGS-based molecular diagnostics and, based thereupon, personalized treatment information within the national Network Genomic Medicine (nNGM) lung cancer regular clinical follow-up visits and data documentation in the shared central digital database by participating physicians monthly assessment of patient-reported outcomes (PRO) on quality of life, anxiety, and depression incorporation of PROs into treatment by physicians treatment monitoring and counseling in the case of critical conditions by expert committee
Primary Outcome Measure Information:
Title
Overall Survival (OS)
Description
Overall Survival (OS) will be assessed in months.
Time Frame
up to 34 months
Secondary Outcome Measure Information:
Title
Progression-Free Survival (PFS)
Description
Progression-Free Survival (PFS) will be assessed in months.
Time Frame
up to 34 months
Title
Time on First Treatment (ToT)
Description
Duration under first-line therapy will be assessed in months.
Time Frame
up to 34 months
Title
Hospitalization rate
Description
Frequency of hospital stays will be assessed using health insurance data.
Time Frame
up to 34 months
Title
Quality of Life (EORTC QLQ-C30)
Description
Quality of Life (European Organisation for Research and Treatment of Cancer, Quality of Life Core Questionnaire, EORTC QLQ-C30) will be assessed in absolute values and change over time. Each item is rated on a response scale 1 = "not at all" to 4 = "very much" with exception of the last two items, which assess overall health and quality of life on a scale from 1 = "very poor" to 7 = "excellent". All EORTC QLQ-C30 scale scores range from 0 to 100, whereby higher scores on a functional scale indicate a high level of functioning, whereas higher scores on a symptom scale/symptom item indicate greater symptom burden.
Time Frame
up to 34 months
Title
Quality of Life (EORTC QLQ-LC29)
Description
Quality of Life (European Organisation for Research and Treatment of Cancer, Quality of Life Questionnaire Lung Cancer, EORTC QLQ-LC29) will be assessed in absolute values and change over time. Each item is rated on a response scale 1 = "not at all" to 4 = "very much" and refer to the time frame "during the past week". All EORTC QLQ-LC29 scale scores range from 0 to 100, whereby higher scores for a symptom scale/symptom item indicate greater symptom burden.
Time Frame
up to 34 months
Title
Symptoms of anxiety (GAD-2)
Description
Symptoms of anxiety (Generalized Anxiety Disorder Scale-2, GAD-2) will be assessed in absolute values and change over time. Each item is rated on a response scale 0 = "not at all" to 3 = "nearly every day" and refer to the time frame "during the past two weeks". Higher scores indicate greater symptom burden.
Time Frame
up to 34 months
Title
Symptoms of depression (PHQ-2)
Description
Symptoms of depression (Patient-Health-Questionnaire-2, PHQ-2) will be assessed in absolute values and change over time. Each item is rated on a response scale 0 = "not at all" to 3 = "nearly every day" and refer to the time frame "during the past two weeks". Higher scores indicate greater symptom burden.
Time Frame
up to 34 months
Title
Frequency of applied targeted molecular therapies based on clinical therapy information from the MURIEL database
Description
The frequency of applied targeted molecular therapies is based on clinical therapy information from the MURIEL database.
Time Frame
up to 34 months
Title
Frequency of active contact of the expert advisory board with physicians during the course of treatment
Description
Assessing the frequency of the expert advisory board actively contacting physicians during the course of treatment
Time Frame
up to 34 months
Title
Completeness of the documentation of the treatment course
Description
Assessing the completeness of the documentation of the treatment course (DigiNet study visits) in %.
Time Frame
up to 34 months
Title
Frequency of patients' completing the PROs
Description
Assessing the frequency of patients' completing the patient-reported outcomes (PRO) via the internet portal
Time Frame
up to 34 months
Title
Cost-effectiveness of DigiNet compared to standard care in terms of incremental costs per life years gained
Description
Assessing the cost-effectiveness of DigiNet compared to standard care in terms of incremental costs per life years gained
Time Frame
up to 34 months
Title
Cost-effectiveness of DigiNet compared to standard care in terms of costs per quality-adjusted life year [QALY]
Description
Assessing the cost-effectiveness of DigiNet compared to standard care in terms of costs per quality-adjusted life year [QALY]
Time Frame
up to 34 months
Title
Cost of implementation related to DigiNet from the service provider perspective (hospital, practices)
Description
Assessing the cost of implementation related to DigiNet from the service provider perspective (hospital, practices) in Euro (€)
Time Frame
up to 34 months
Title
Process costs related to DigiNet from the service provider perspective (hospital, practices)
Description
Assessing the process costs related to DigiNet from the service provider perspective (hospital, practices) in Euro (€)
Time Frame
up to 34 months
Title
Formative evaluation
Description
Formative evaluation regarding the implementation will be conducted using qualitative analysis of semi-structured interviews
Time Frame
up to 34 months

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Patients diagnosed with advanced NSCLC, stage IV Age > 18 years Life expectancy at least 4 weeks (initial assessment at inclusion in nNGM and confirmation at baseline (implementation of treatment decision)) Exclusion Criteria: Missing informed consent Illnesses and behaviors that impair compliance (e.g., dementia, addictive disorders) Severely impaired general physical condition that no longer permits therapy for lung cancer
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Anna Kron, Dr.
Phone
+49 221 478-96775
Email
anna.kron@uk-koeln.de
First Name & Middle Initial & Last Name or Official Title & Degree
Leonie Eilers, MSc
Phone
+49 22180147848
Email
leonie.eilers@bcw-gruppe.de
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Jürgen Wolf, Prof. Dr.
Organizational Affiliation
Uniklinik Köln
Official's Role
Principal Investigator
Facility Information:
Facility Name
Hämatologisch-Onkologische Schwerpunktpraxis
City
Bad Liebenwerda
State/Province
Brandenburg
ZIP/Postal Code
04924
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
Phone
+49 35341 475134
Email
info@onkologie-badliebenwerda.de
First Name & Middle Initial & Last Name & Degree
Stephan Kreher, PD Dr. med.
Facility Name
Johanniter-Krankenhaus Bonn
City
Bonn
State/Province
NRW
ZIP/Postal Code
53113
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yon-Dschun Ko, Prof. Dr.
Phone
+49 228 543-2201
Email
Yon-Dschun.ko@johanniter-kliniken.de
First Name & Middle Initial & Last Name & Degree
Yon-Dschun Ko, Prof. Dr.
Facility Name
Universitätsklinikum Bonn (UKB)
City
Bonn
State/Province
NRW
ZIP/Postal Code
53127
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Franz G. Bauernfeind, Dr. med.
Phone
+49 228 287-17059
Email
franz-georg.bauernfeind@ukbonn.de
First Name & Middle Initial & Last Name & Degree
Franz G. Bauernfeind, Dr. med.
Facility Name
Zentrum für ambulante Hämatologie und Onkologie Rhein-Sieg (ZAHO)
City
Brühl
State/Province
NRW
ZIP/Postal Code
50321
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sebastian Stier, PD. Dr. med.
Phone
+49 2232 504010
Email
sstier@zaho-rheinland.de
First Name & Middle Initial & Last Name & Degree
Sebastian Stier, PD Dr. med.
Facility Name
Klinikum Dortmund GmbH
City
Dortmund
State/Province
NRW
ZIP/Postal Code
44137
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Bernhard Schaaf, PD Dr. med.
Phone
+49 231 95318190
Email
bernhard.schaaf@klinikumdo.de
First Name & Middle Initial & Last Name & Degree
Bernhard Schaaf, PD Dr. med.
Facility Name
Gemeinschaftspraxis für Hämatologie & Onkologie
City
Dortmund
State/Province
NRW
ZIP/Postal Code
44263
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Monika Ludwig, Dr.
Phone
+49 231 206 1692
Email
monika.ludwig@gefos-dortmund.de
First Name & Middle Initial & Last Name & Degree
Clemens Schulte, Dr. med. MBA
First Name & Middle Initial & Last Name & Degree
Sandra Ketzler-Henkel
Facility Name
Universitätsklinikum Düsseldorf (UKD)
City
Düsseldorf
State/Province
NRW
ZIP/Postal Code
40225
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Stephanie Keymel, Dr. med.
Phone
+49 211 8117897
Email
Stefanie.Keymel@med.uni-duesseldorf.de
First Name & Middle Initial & Last Name & Degree
Stephanie Keymel, Dr. med.
Facility Name
Universitätsklinikum Essen
City
Essen
State/Province
NRW
ZIP/Postal Code
45147
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Martin Schuler, Prof. Dr.
Phone
+49 201 723 20 00
Email
Martin.Schuler@uk-essen.de
First Name & Middle Initial & Last Name & Degree
Martin Schuler, Prof. Dr.
Facility Name
Onkologische Gemeinschaftspraxis
City
Gütersloh
State/Province
NRW
ZIP/Postal Code
33332
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Philipp Schütt, PD Dr. med.
Phone
+49 5241 8328100
Email
schuett@onkologie-guetersloh.de
First Name & Middle Initial & Last Name & Degree
Philipp Schütt, PD Dr. med.
Facility Name
Praxis für Hämatologie und Internistische Onkologie
City
Hamm
State/Province
NRW
ZIP/Postal Code
59065
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Oliver Christ, Dr. med.
Phone
+49 2381 94304-0
Email
o.christ@onkologie-hamm.de
First Name & Middle Initial & Last Name & Degree
Oliver Christ, Dr. med.
Facility Name
MV-Zentrum für Hämatologie und Onkologie
City
Köln
State/Province
NRW
ZIP/Postal Code
50677
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jan Weber, Dr. med.
Phone
+49 221 931822 0
Email
Weber@oncokoeln.de
First Name & Middle Initial & Last Name & Degree
Kai Severin, Dr. med.
First Name & Middle Initial & Last Name & Degree
Stephan Schmitz, Prof. Dr.
First Name & Middle Initial & Last Name & Degree
Tilman Steinmetz, Dr. med.
First Name & Middle Initial & Last Name & Degree
Jan Weber, Dr. med.
Facility Name
Universitätsklinikum Köln
City
Köln
State/Province
NRW
ZIP/Postal Code
50937
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Anna Kron, Dr.
Phone
+49 221 478-96775
Email
anna.kron@uk-koeln.de
First Name & Middle Initial & Last Name & Degree
Jürgen Wolf, Prof. Dr.
Facility Name
MVZ West GmbH Standort Köln-Kalk
City
Köln
State/Province
NRW
ZIP/Postal Code
51103
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Nathalie Bauer, Dr.
Phone
+4922198944717
Email
bod.dr.nathalie.bauer@gmail.com
First Name & Middle Initial & Last Name & Degree
Achim Rothe, PD Dr. med.
Facility Name
Praxis Internistischer Onkologie und Hämatologie (pioh)
City
Köln
State/Province
NRW
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Matthias Hellmann, Dr. med.
First Name & Middle Initial & Last Name & Degree
Roland Schnell, PD Dr. med.
First Name & Middle Initial & Last Name & Degree
Holger Schulz, Dr. med.
First Name & Middle Initial & Last Name & Degree
Julia Lukanowski, Dr. med.
First Name & Middle Initial & Last Name & Degree
Marcel Reiser, PD Dr. med.
First Name & Middle Initial & Last Name & Degree
Andreas Draube, PD Dr. med.
Facility Name
Klinikum Leverkusen
City
Leverkusen
State/Province
NRW
ZIP/Postal Code
51375
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Utz Krug, PD Dr. med.
Phone
+49 214 132671
Email
utz.krug@klinikum-lev.de
First Name & Middle Initial & Last Name & Degree
Utz Krug, PD Dr. med.
Facility Name
Märkische Kliniken GmbH, Klinikum Lüdenscheid
City
Lüdenscheid
State/Province
NRW
ZIP/Postal Code
58515
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Karl-Josef Franke, PD Dr. med.
Phone
+49 2351 463360
Email
karl.josef.franke@klinikum-luedenscheid.de
First Name & Middle Initial & Last Name & Degree
Karl-Josef Franke, PD Dr. med.
Facility Name
Kliniken Maria Hilf GmbH
City
Mönchengladbach
State/Province
NRW
ZIP/Postal Code
41063
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ullrich Graeven, Prof. Dr.
Phone
+49 2161 8922201
Email
ullrich.graeven@mariahilf.de
First Name & Middle Initial & Last Name & Degree
Ullrich Graeven, Prof. Dr.
Facility Name
MVZ für Hämatologie und Onkologie
City
Mülheim an der Ruhr
State/Province
NRW
ZIP/Postal Code
45468
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
Phone
+49 208 76981
Email
praxis@onkologie-mh.de
First Name & Middle Initial & Last Name & Degree
Jan Schröder, PD Dr. med.
Facility Name
Praxis und Tagesklinik für Internistische Onkologie und Hämatologie
City
Recklinghausen
State/Province
NRW
ZIP/Postal Code
45659
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Till-Oliver Emde
Phone
+49 2361 904270
Email
emde@onkologie-re.de
First Name & Middle Initial & Last Name & Degree
Till-Oliver Emde
Facility Name
Krankenhaus Bethanien Solingen
City
Solingen
State/Province
NRW
ZIP/Postal Code
42699
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Britta Kaminsky, Dr. med.
Phone
+49 212 636730
Email
britta.kaminsky@klinik-bethanien.de
First Name & Middle Initial & Last Name & Degree
Britta Kaminsky, Dr. med.
Facility Name
Onkologie Rheinsieg
City
Troisdorf/Bonn-Beuel/Bad Honnef
State/Province
NRW
ZIP/Postal Code
53840
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ernst Rodermann, Dr. med.
Phone
+49 2241-39 75 66 0
Email
rodermann@onkologie-rheinsieg.de
First Name & Middle Initial & Last Name & Degree
Helmut Forstbauer, Dr. med.
First Name & Middle Initial & Last Name & Degree
Ruth Reihs, Dr. med.
First Name & Middle Initial & Last Name & Degree
Ernst Rodermann, Dr. med.
First Name & Middle Initial & Last Name & Degree
Andreas Diehl
First Name & Middle Initial & Last Name & Degree
Anke Herfort, Dr. med.
Facility Name
MVZ Medizinisches Versorgungszentrum am Marien-Hospital Wesel
City
Wesel
State/Province
NRW
ZIP/Postal Code
46483
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
Phone
+49 281 1041910
Email
onkologie.mvz@prohomine.de
First Name & Middle Initial & Last Name & Degree
Mathias Hoiczyk, Dr. med.
Facility Name
Medizinisches Versorgungzentrum am Evangelischen Krankenhaus Wesel GmbH
City
Wesel
State/Province
NRW
ZIP/Postal Code
46485
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Michael Trapp, Dr. med.
Phone
+49 (0) 2811 062344
Email
michael.trapp@mvzevkwesel.de
First Name & Middle Initial & Last Name & Degree
Michael Trapp, Dr. med.
Facility Name
Onkologie Erzgebirge
City
Aue-Bad Schlema
State/Province
Sachsen
ZIP/Postal Code
08301
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Marcus Rönitz, Dr. med.
Phone
+49 3772 381933
Email
roenitz@onkologie-erzgebirge.de
First Name & Middle Initial & Last Name & Degree
Andreas Thiel, Dr. med.
Facility Name
Hämatologisch Onkologisches Centrum Ostsachsen ONCOS GmbH
City
Bautzen
State/Province
Sachsen
ZIP/Postal Code
02625
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
Phone
+49 35 91 404 24
Email
praxis@oncos.de
First Name & Middle Initial & Last Name & Degree
Conrad Heuchel, Dr. med.
Facility Name
Fachkrankenhaus Coswig
City
Coswig
State/Province
Sachsen
ZIP/Postal Code
01640
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Dirk Koschel, Dr. med.
Phone
+49 3523 65202
Email
koschel@fachkrankenhaus-coswig.de
First Name & Middle Initial & Last Name & Degree
Dirk Koschel, Dr. med.
Facility Name
Onkozentrum Dresden/Freiberg/Meißen
City
Dresden/Freiberg/Meißen
State/Province
Sachsen
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
Phone
+49 351 795 255-0
Email
goehler@onkozentrum.de
First Name & Middle Initial & Last Name & Degree
Thomas Boldt
First Name & Middle Initial & Last Name & Degree
Thomas Göhler, Dr. med.
First Name & Middle Initial & Last Name & Degree
Steffen Dörfel, Dipl.-Med.
First Name & Middle Initial & Last Name & Degree
Sebastian Thiele, Dr. med.
First Name & Middle Initial & Last Name & Degree
Michael Hering
Facility Name
Gemeinschaftspraxis Dr. med. Johannes Mohm Dr. med. Gabriele Prange-Krex
City
Dresden
State/Province
Sachsen
ZIP/Postal Code
01307
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
Phone
+49 351 44 16018
Email
info@onkopraxis-dresden.de
First Name & Middle Initial & Last Name & Degree
Johannes Mohm, Dr. med.
Facility Name
Gemeinschaftspraxis Hämatologie - Onkologie
City
Dresden
State/Province
Sachsen
ZIP/Postal Code
01307
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
Phone
+49 351-447 23 4 0
First Name & Middle Initial & Last Name & Degree
Jens Freiberg-Richter, Dr. med.
First Name & Middle Initial & Last Name & Degree
Thomas Illmer, PD Dr. med.
Facility Name
Universitätsklinikum Carl Gustav Carus Dresden
City
Dresden
State/Province
Sachsen
ZIP/Postal Code
01307
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Martin Wermke, Dr. med.
Phone
+49 351-458 4695
Email
martin.wermke@uniklinikum-dresden.de
First Name & Middle Initial & Last Name & Degree
Martin Wermke, Dr. med.
Facility Name
Ev. Diakonissenkrankenhaus Leipzig
City
Leipzig
State/Province
Sachsen
ZIP/Postal Code
04177
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sylvia Gütz, Dr. med.
Phone
+49 341 4445840
Email
sylvia.guetz@ediacon.de
First Name & Middle Initial & Last Name & Degree
Sylvia Gütz, Dr. med.
Facility Name
Ambulante Onkologie Ostsachsen
City
Zittau
State/Province
Sachsen
ZIP/Postal Code
02763
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mathias Schulze, Dr. med.
Phone
+49 3583 696554
Email
praxis-dr.mathias.schulze@online.de
First Name & Middle Initial & Last Name & Degree
Mathias Schulze, Dr. med.
First Name & Middle Initial & Last Name & Degree
Ute Funke, Dr. med.
Facility Name
Helios Klinikum Erfurt
City
Erfurt
State/Province
Thüringen
ZIP/Postal Code
99089
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jens-Uwe Bauer, Dr. med.
Phone
+49 361 781-2581
Email
jens-uwe.bauer@helios-gesundheit.de
First Name & Middle Initial & Last Name & Degree
Jens-Uwe Bauer, Dr. med.
Facility Name
Alexianer St. Hedwig Kliniken Berlin GmbH
City
Berlin
ZIP/Postal Code
10115
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alexander Kühnemund, Dr. med.
Phone
+49 30 23112868
Email
a.kuehnemund@alexianer.de
First Name & Middle Initial & Last Name & Degree
Alexander Kühnemund, Dr. med.
Facility Name
Charité Universitätsmedizin Berlin
City
Berlin
ZIP/Postal Code
10117
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ulrich Keilholz, Prof. Dr.
Phone
+49 30 450 564 222
Email
Ulrich.Keilholz@charite.de
First Name & Middle Initial & Last Name & Degree
Ulrich Keilholz, Prof. Dr.
Facility Name
Onkologische Schwerpunktpraxis Tiergarten
City
Berlin
ZIP/Postal Code
10559
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
Phone
+49 30 394 20 03
Email
anmeldung@onkologie-tiergarten.de
First Name & Middle Initial & Last Name & Degree
Dorothea Kingreen, Dr. med.
First Name & Middle Initial & Last Name & Degree
Antja Koschuth, Dr. med.
First Name & Middle Initial & Last Name & Degree
Jobst von Einem, Dr. med.
Facility Name
Onkologische Schwerpunktpraxis Kurfürstendamm
City
Berlin
ZIP/Postal Code
10707
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ingo Schwaner, Dr. med.
Phone
+49 30 88 77 42 57 0
Email
ingo.schwaner@onkologie-kurfuerstendamm.de
First Name & Middle Initial & Last Name & Degree
Ingo Schwaner, Dr. med.
Facility Name
Praxis am Volkspark
City
Berlin
ZIP/Postal Code
10715
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
Phone
+49 30 84 72 35 35
Email
info@praxis-am-volkspark-berlin.de
First Name & Middle Initial & Last Name & Degree
Oliver Schulz, Dr. med.
First Name & Middle Initial & Last Name & Degree
Meike Kollendt, Dr. med.
Facility Name
Vivantes Klinikum Neukölln
City
Berlin
ZIP/Postal Code
12351
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sven Gläser, Prof. Dr.
Phone
+49 30 130 142030
Email
Sven.Glaeser@vivantes.de
First Name & Middle Initial & Last Name & Degree
Sven Gläser, Prof. Dr.
Facility Name
Evangelische Lungenklinik Berlin
City
Berlin
ZIP/Postal Code
13125
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Christian Grohé, Prof. Dr.
Phone
+49 30 948020
Email
christian.grohe@elk-berlin.de
First Name & Middle Initial & Last Name & Degree
Christian Grohé, Prof. Dr.
Facility Name
Onkologie Seestraße
City
Berlin
ZIP/Postal Code
13347
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
Phone
+49 30 76 90 90 90
Email
praxis@onkologie-seestrasse.de
First Name & Middle Initial & Last Name & Degree
Jan Siehl, Dr. med.
First Name & Middle Initial & Last Name & Degree
Susanne Ganepola, Dr. med.
First Name & Middle Initial & Last Name & Degree
Ronny Schuster, Dr. med. Dr.
First Name & Middle Initial & Last Name & Degree
Alexander Schmittel, PD Dr. med.
Facility Name
DRK Kliniken Berlin Mitte
City
Berlin
ZIP/Postal Code
13359
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Bernd Schmidt, Prof. Dr.
Phone
+49 30 30356300
Email
b.schmidt@drk-kliniken-berlin.de
First Name & Middle Initial & Last Name & Degree
Bernd Schmidt, Prof. Dr.
Facility Name
Lungenarztpraxis Tegel
City
Berlin
ZIP/Postal Code
13507
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
Phone
+49 30 4403070 20
Email
mail@lungenarztpraxis-tegel.de
First Name & Middle Initial & Last Name & Degree
Vincent van Laak, Dr. med.
First Name & Middle Initial & Last Name & Degree
Daniel Binder, Dr. med.
Facility Name
Gemeinschaftskrankenhaus Havelhöhe
City
Berlin
ZIP/Postal Code
14089
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Christian Grah, Dr. med.
Phone
+49 3650 17020
Email
christian.grah@havelhoehe.de
First Name & Middle Initial & Last Name & Degree
Christian Grah, Dr. med.
Facility Name
Helios Klinikum Emil von Behring
City
Berlin
ZIP/Postal Code
14165
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Susann Stephan-Falkenau, Dr. med.
Phone
+49 30 8102 63580
Email
susann.stephan-falkenau@helios-gesundheit.de
First Name & Middle Initial & Last Name & Degree
Susann Stephan-Falkenau, Dr. med.
Facility Name
Onkologischer Schwerpunkt am Oskar-Helene-Heim
City
Berlin
ZIP/Postal Code
14195
Country
Germany
Individual Site Status
Recruiting
Facility Contact:
Phone
+49 30 644 99 5230
Email
info@onkologie-ohh.de
First Name & Middle Initial & Last Name & Degree
Markus Schuler, PD Dr. med.

12. IPD Sharing Statement

Plan to Share IPD
No
Links:
URL
https://diginet.nngm.de/
Description
Project Website

Learn more about this trial

Improvement of Personalized Lung Cancer Care Through Digital Connection and Patient Participation (DigiNet)

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