Functional Coronary Angiography Guided Revascularization in STEMI (AIR-STEMI)
Myocardial Infarction
About this trial
This is an interventional treatment trial for Myocardial Infarction focused on measuring Percutaneous coronary intervention, Angiography-derived Fractional Flow Reserve, Multivessel disease
Eligibility Criteria
Inclusion Criteria: ST-segment elevation myocardial infarction with indication to invasive management Multi-vessel disease defined as at least 1 non-culprit coronary artery lesion at least 2.5 mm in diameter deemed at visual estimation with a diameter stenosis % ranging from 50 to 99% amenable to successful treatment with PCI Successful treatment of culprit lesion Exclusion Criteria: Planned surgical revascularization Left main as non-culprit lesion Non-cardiovascular co-morbidity reducing life expectancy to < 1 year Any factor precluding 1-year follow-up Prior Coronary Artery Bypass Graft (CABG) Surgery Impossibility to identify a clear culprit lesion Presence of a chronic total occlusion (CTO)
Sites / Locations
- AUSL Bologna Ospedale MaggioreRecruiting
- Azienda Ospedaliero Universitaria di FerraraRecruiting
- Ospedale Civile di BaggiovaraRecruiting
- AUSL PiacenzaRecruiting
- Azienda Ospedaliero Universitaria di ParmaRecruiting
- Arcispedale Santa Maria Nuova di Reggio EmiliaRecruiting
- AUSL Romagna Ospedale degli Infermi RiminiRecruiting
- Ospedale Santa Maria della Misericordia RovigoRecruiting
- Ospedale dell'Angelo MestreRecruiting
- Ospedale Mater Salutis LegnagoRecruiting
- Azienda Ospedaliero Universitaria Integrata di VeronaRecruiting
- Ospedale Santa Maria GorettiRecruiting
- Ospedale Maggiore della Carità NovaraRecruiting
- AUSL Romagna Santa Maria delle Croci RavennaRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
Angiography-guided PCI
Angiography-derived FFR PCI indication and planning
Patients will receive PCI of all lesions with at least 50% diameter stenosis at visual estimation. PCI plan and assessment of PCI results will be based on angiography.
Patients will receive PCI of all lesions with at least 50% diameter stenosis and positive angiography-derived FFR value (≤0.80). PCI planning will be based on the pullback curve obtained by angiography-derived FFR to obtain an optimal post-PCI physiology.