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Racial Discrimination and Stress Response

Primary Purpose

Stress Reaction; Acute

Status
Recruiting
Phase
Not Applicable
Locations
United States
Study Type
Interventional
Intervention
peer rejection task and impossible puzzle task
Sponsored by
Western Kentucky University
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional basic science trial for Stress Reaction; Acute focused on measuring cardiovascular reactivity, hypothalamic-pituitary-adrenal axis, inflammatory mediator, subtle racism

Eligibility Criteria

11 Years - 69 Years (Child, Adult, Older Adult)All SexesAccepts Healthy Volunteers

Inclusion Criteria: 6th-8th graders identified as Latino American or Black/African American Living in Warren county of Kentucky Parents of eligible adolescents Exclusion Criteria: Adolescents will not participate in the peer rejection task when they report to have: frequent experiences of peer victimization frequent experiences of racial discrimination severe depression severe social anxiety disorder severe generalized anxiety disorder

Sites / Locations

  • Western Kentucky UniversityRecruiting

Arms of the Study

Arm 1

Arm Type

Experimental

Arm Label

stress inducing task

Arm Description

Adolescents will complete an adapted peer rejection task on the computer to elicit the experience of subtle racial discrimination from White peers, as well as an impossible puzzle task to elicit cognitive stress.

Outcomes

Primary Outcome Measures

change in blood pressure for peer rejection
participants' diastolic and systolic blood pressure will be continuously monitored.
change in stress hormones for peer rejection
participants' salivary samples will be collected, frozen, and assayed for cortisol.
change in inflammatory biomarker of Interleukin 6 for peer rejection
participants' salivary samples will be collected, frozen, and assayed for inflammatory biomarker of Interleukin-6
change in inflammatory biomarker of C-reactive protein for peer rejection
participants' salivary samples will be collected, frozen, and assayed for inflammatory biomarker of C-reactive protein
attribution about the peer rejection for peer rejection
participants will complete the questionnaire, Attribution About The Peer Rejection (AATPR) to rate the likelihood of various reasons for the experience of peer rejection using a 7-point scale. The higher total score for the 4 racial reasons (possible range: 4-28) indicates the higher tendency of making racial attribution about the peer rejection.
emotional experience for peer rejection
participants will complete the questionnaire, Emotions In The Peer Rejection (EITPR) to rate the emotional experiences in the peer rejection task using a 7-point scale. The higher total score for 5 sets of emotion terms (possible range: 5-35) indicates the higher levels of negative emotions in the peer rejection task.
change in skin conductance activity for peer rejection
participants' skin conductance will be continuously monitored for the peer rejection task.
change in respiratory sinus arrhythmia for peer rejection
participants' electrocardiogram data that can be used to extract respiratory sinus arrhythmia, heart rate variability in synchrony with respiration, will be continuously monitored for the peer rejection task.

Secondary Outcome Measures

change in cardiovascular activity for impossible puzzle
participants' systolic and diastolic blood pressure will be continuously monitored for the impossible puzzle task
attribution for impossible puzzle
participants will complete the questionnaire, Attribution About The Impossible Puzzle (AATIP) to rate the likelihood of various reasons for the experience of not being able to complete the puzzle using a 7-point scale. The higher total score for the 3 intrinsic reasons (possible range: 3-21) indicates the higher tendency of making intrinsic attribution about performance in the impossible puzzle task.
emotional experience for impossible puzzle
participants will complete the questionnaire, Emotions In The Impossible Puzzle (EITIP) to rate the emotional experiences in the impossible puzzle task using a 7-point scale. The higher total score for 5 sets of emotion terms (possible range: 5-35) indicates the higher levels of negative emotions in the impossible puzzle task
change in skin conductance for impossible puzzle
participants' skin conductance will be continuously monitored for the impossible puzzle task
change in respiratory sinus arrhythmia for impossible puzzle
participants' electrocardiogram data that can be used to extract respiratory sinus arrhythmia, heart rate variability in synchrony with respiration, will be continuously monitored for the impossible puzzle task

Full Information

First Posted
March 29, 2023
Last Updated
July 1, 2023
Sponsor
Western Kentucky University
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1. Study Identification

Unique Protocol Identification Number
NCT05820659
Brief Title
Racial Discrimination and Stress Response
Official Title
Racial Discrimination and Dysregulated Stress Response: Risk/Protective Factors
Study Type
Interventional

2. Study Status

Record Verification Date
April 2023
Overall Recruitment Status
Recruiting
Study Start Date
June 29, 2023 (Actual)
Primary Completion Date
April 30, 2025 (Anticipated)
Study Completion Date
April 30, 2025 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Western Kentucky University

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No

5. Study Description

Brief Summary
The goal of this study is to learn about whether ethnic minority adolescents' racial discrimination experience is related to dysregulated biological responses to subtle racism, and how the relationship may be attenuated or exacerbated by a set of social and cognitive factors. The main questions it aims to answer are: to reveal the relationship between racial discrimination experiences and ethnic minority adolescents' stress response to subtle racism to test parental ethnic-racial socialization, children's attribution to subtle racism and their racial identity as potential risk and protective factors.
Detailed Description
Racial discrimination experiences constitute significant risks for ethnic minority youth's physical and mental health problems. One explanation poses that chronic stress can lead to altered, dysregulated stress responses, which can make individuals susceptible to health problems. Currently, there is no experimental study that comprehensively measure ethnic minority youth's stress response to subtle racism, or investigate the contributing roles of racial discrimination experience and possible risk and protective factors. A community sample of 11-14-year-old ethnic minority adolescents (40 Latino American, 40 Black/African American) and their parents will be recruited. The study employs an adapted peer rejection task which has been widely used with youth, and carefully designed to elicit the experience of subtle racial discrimination from White peers. Adolescents' cardiovascular activity and saliva samples will be taken at multiple time points before, during, and after the peer rejection task, tapping on response involving hypothalamic-pituitary-adrenal (HPA) axis, autonomic nervous system (ANS), and inflammatory mediator (IM). Adolescents will report their racial discrimination experience, make attribution about the peer rejection experience, report emotional experience, and rate their racial identity. Adolescents will complete an impossible puzzle task to elicit cognitive stress, during which they will be asked to fit all puzzle pieces into a wooden frame with a wrong piece provided. Their cardiovascular activity, attribution, and emotional experience in response to the impossible puzzle task will be measured. Parents will complete a questionnaire to report their ethnic-racial socialization practices. The goals of this proposal are: 1) Reveal the relationship between racial discrimination experiences and ethnic minority adolescents' stress response to subtle racism as well as to cognitive stress; and 2) Test parental ethnic-racial socialization, children's attribution to subtle racism and their racial identity as potential risk and protective factors.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Stress Reaction; Acute
Keywords
cardiovascular reactivity, hypothalamic-pituitary-adrenal axis, inflammatory mediator, subtle racism

7. Study Design

Primary Purpose
Basic Science
Study Phase
Not Applicable
Interventional Study Model
Single Group Assignment
Masking
None (Open Label)
Allocation
N/A
Enrollment
160 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
stress inducing task
Arm Type
Experimental
Arm Description
Adolescents will complete an adapted peer rejection task on the computer to elicit the experience of subtle racial discrimination from White peers, as well as an impossible puzzle task to elicit cognitive stress.
Intervention Type
Behavioral
Intervention Name(s)
peer rejection task and impossible puzzle task
Intervention Description
Peer rejection task: Adolescents will be informed that two peers will take turns to choose who they will chat with for different topics. Participants will not be chosen by virtual White peers 75% of the time. In reality, White peers are computerized avatars and whether or not adolescents are chosen by those peers is programmed with PsychoPy software. Impossible puzzle task: Adolescents will be asked to fit all puzzle pieces into a wooden frame with a wrong piece provided.
Primary Outcome Measure Information:
Title
change in blood pressure for peer rejection
Description
participants' diastolic and systolic blood pressure will be continuously monitored.
Time Frame
participants' blood pressure will be continuously monitored 10 minute before, during, and 45 minutes after the peer rejection task.
Title
change in stress hormones for peer rejection
Description
participants' salivary samples will be collected, frozen, and assayed for cortisol.
Time Frame
participants' salivary samples will be collected at five time points (right before, 5 minutes after, 15 minutes after, 30 minutes after, and 45 minutes after the peer rejection task)
Title
change in inflammatory biomarker of Interleukin 6 for peer rejection
Description
participants' salivary samples will be collected, frozen, and assayed for inflammatory biomarker of Interleukin-6
Time Frame
participants' salivary samples will be collected at five time points (right before, 5 minutes after, 15 minutes after, 30 minutes after, and 45 minutes after the peer rejection task)
Title
change in inflammatory biomarker of C-reactive protein for peer rejection
Description
participants' salivary samples will be collected, frozen, and assayed for inflammatory biomarker of C-reactive protein
Time Frame
participants' salivary samples will be collected at five time points (right before, 5 minutes after, 15 minutes after, 30 minutes after, and 45 minutes after the peer rejection task)
Title
attribution about the peer rejection for peer rejection
Description
participants will complete the questionnaire, Attribution About The Peer Rejection (AATPR) to rate the likelihood of various reasons for the experience of peer rejection using a 7-point scale. The higher total score for the 4 racial reasons (possible range: 4-28) indicates the higher tendency of making racial attribution about the peer rejection.
Time Frame
right after the peer rejection task
Title
emotional experience for peer rejection
Description
participants will complete the questionnaire, Emotions In The Peer Rejection (EITPR) to rate the emotional experiences in the peer rejection task using a 7-point scale. The higher total score for 5 sets of emotion terms (possible range: 5-35) indicates the higher levels of negative emotions in the peer rejection task.
Time Frame
right after the peer rejection task
Title
change in skin conductance activity for peer rejection
Description
participants' skin conductance will be continuously monitored for the peer rejection task.
Time Frame
participants' skin conductance will be continuously monitored 10 minutes before, during, and 45 minutes after the peer rejection task
Title
change in respiratory sinus arrhythmia for peer rejection
Description
participants' electrocardiogram data that can be used to extract respiratory sinus arrhythmia, heart rate variability in synchrony with respiration, will be continuously monitored for the peer rejection task.
Time Frame
participants' electrocardiogram data will be continuously monitored 10 minutes before, during, and 45 minutes after the peer rejection task
Secondary Outcome Measure Information:
Title
change in cardiovascular activity for impossible puzzle
Description
participants' systolic and diastolic blood pressure will be continuously monitored for the impossible puzzle task
Time Frame
participants' systolic and diastolic blood pressure will be continuously monitored 6 minutes before, during, and 15 minutes after the impossible puzzle task
Title
attribution for impossible puzzle
Description
participants will complete the questionnaire, Attribution About The Impossible Puzzle (AATIP) to rate the likelihood of various reasons for the experience of not being able to complete the puzzle using a 7-point scale. The higher total score for the 3 intrinsic reasons (possible range: 3-21) indicates the higher tendency of making intrinsic attribution about performance in the impossible puzzle task.
Time Frame
right after the impossible puzzle task
Title
emotional experience for impossible puzzle
Description
participants will complete the questionnaire, Emotions In The Impossible Puzzle (EITIP) to rate the emotional experiences in the impossible puzzle task using a 7-point scale. The higher total score for 5 sets of emotion terms (possible range: 5-35) indicates the higher levels of negative emotions in the impossible puzzle task
Time Frame
right after the impossible puzzle task
Title
change in skin conductance for impossible puzzle
Description
participants' skin conductance will be continuously monitored for the impossible puzzle task
Time Frame
participants' skin conductance will be continuously monitored 6 minutes before, during, and 15 minutes after the impossible puzzle task
Title
change in respiratory sinus arrhythmia for impossible puzzle
Description
participants' electrocardiogram data that can be used to extract respiratory sinus arrhythmia, heart rate variability in synchrony with respiration, will be continuously monitored for the impossible puzzle task
Time Frame
participants' electrocardiogram data will be continuously monitored 6 minutes before, during, and 15 minutes after the impossible puzzle task

10. Eligibility

Sex
All
Minimum Age & Unit of Time
11 Years
Maximum Age & Unit of Time
69 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: 6th-8th graders identified as Latino American or Black/African American Living in Warren county of Kentucky Parents of eligible adolescents Exclusion Criteria: Adolescents will not participate in the peer rejection task when they report to have: frequent experiences of peer victimization frequent experiences of racial discrimination severe depression severe social anxiety disorder severe generalized anxiety disorder
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Qingfang Song, Ph.D.
Phone
(270)745-4229
Email
qingfang.song@wku.edu
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Qingfang Song, Ph.D
Organizational Affiliation
Western Kentucky University
Official's Role
Principal Investigator
Facility Information:
Facility Name
Western Kentucky University
City
Bowling Green
State/Province
Kentucky
ZIP/Postal Code
42101
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Qingfang Song, Ph.D.
Phone
270-745-4229
Email
qingfang.song@wku.edu

12. IPD Sharing Statement

Plan to Share IPD
Yes
IPD Sharing Plan Description
The research resources from the project will include the study protocol and associated data, which will be provided upon request.
IPD Sharing Time Frame
The protocol and deidentified data will become available six months after the first publication.
IPD Sharing Access Criteria
Data will be shared upon individual request.
Citations:
PubMed Identifier
27806018
Citation
Lucas T, Wegner R, Pierce J, Lumley MA, Laurent HK, Granger DA. Perceived Discrimination, Racial Identity, and Multisystem Stress Response to Social Evaluative Threat Among African American Men and Women. Psychosom Med. 2017 Apr;79(3):293-305. doi: 10.1097/PSY.0000000000000406.
Results Reference
background
PubMed Identifier
21775386
Citation
Silk JS, Stroud LR, Siegle GJ, Dahl RE, Lee KH, Nelson EE. Peer acceptance and rejection through the eyes of youth: pupillary, eyetracking and ecological data from the Chatroom Interact task. Soc Cogn Affect Neurosci. 2012 Jan;7(1):93-105. doi: 10.1093/scan/nsr044. Epub 2011 Jul 20.
Results Reference
background
PubMed Identifier
33933893
Citation
Sladek MR, Castro SA, Doane LD. Ethnic-Racial discrimination experiences predict Latinx adolescents' physiological stress processes across college transition. Psychoneuroendocrinology. 2021 Jun;128:105212. doi: 10.1016/j.psyneuen.2021.105212. Epub 2021 Apr 1.
Results Reference
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Racial Discrimination and Stress Response

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