Deucravacitinib in PG

Inclusion Criteria: Men and women between the ages of 18-70 years old Diagnosed with pyoderma gangrenosum requiring one major and at least 4 minor criteria Women must not be pregnant, lactating, or planning pregnancy during the study period Women of child-bearing potential must be on birth control for the duration of the treatment period. Subjects must agree to the use of at least one of the following contraception methods for the entire duration of the study until at least 30 days after taking their last dose of study drug: Women: Hormonal contraception (oral, injections, patch, implant, or vaginal-ring); Spiral (with or without hormones); any sterilization methods; a partner who has had a vasectomy; or sexual abstinence. Other acceptable methods of contraception are male or female condoms (with or without spermicide) or a cap, diaphragm, or sponge with spermicide. Willing to discontinue topical and/or systemic therapies, with the exception of oral rescue therapy with steroids. The wash period for systemic therapies will largely depend on the specific treatment but, in general, will be at least 6 months for biologics and 3 months for other immune- suppressants such as cyclosporine, mycophenolate mofetil, methotrexate, etc. No wash out period is required for topicals. Capable and willing to sign Institutional Review Board/IEC-approved written informed consent form in accordance with regulatory and institutional guidelines before the performance of any protocol-related procedures. Exclusion Criteria: Patient under 18 years of age. Patients with a history of inflammatory bowel disease. Patients on systemic immunosuppressive/immune modulating therapy including: oral steroids, cyclosporine, mycophenolate mofetil, methotrexate, Azathioprine or TNFα inhibitor at time of starting deucravacitinib. Patients currently enrolled in another investigational study. Patients with a history or evidence of active infection and/or febrile illness within 7 days; or serious infection requiring antibiotic treatment within 30 days Hepatitis C virus (HCV): subjects known to be positive for anti-HCV antibody or for HCV RNA detectable by polymerase chain reaction (PCR) Hepatitis B virus (HBV): subjects known to be positive for hepatitis B surface antigen or for HBV DNA detectable by PCR Human Immunodeficiency Virus (HIV) infection: subjects known to be HIV positive History of active or inadequately treated latent tuberculosis (TB) Known or suspected systemic or skin autoimmune disorder other than pyoderma gangrenosum Any unstable major illness or evidence of unstable condition of major organ systems including psychiatric Cancer or history of lymphoproliferative disease within last 5 years; exception is cutaneous basal cell carcinoma or squamous cell carcinoma that has been treated. Major surgery within the last 4 weeks Live vaccines within the last 60 days Leukopenia (absolute WBC count < 3000/mm3); Lymphopenia (ALC < 500/mm3); Neutropenia (ANC < 1000/mm3) Thrombocytopenia (platelet count < 100,000/mm3; Anemia (hemoglobin < 9.0g/dL) ALT/AST > 3 X ULN and/or Total, unconjugated, and/or conjugated bilirubin > 2 X ULN within 28 days of dosing