Impact of Pre-operative Penicillin Allergy Evaluation on Surgical Prophylaxis
Penicillin Allergy, Surgical Prophylaxis
About this trial
This is an interventional treatment trial for Penicillin Allergy
Eligibility Criteria
Inclusion Criteria: age 18 years or above planned for clean or clean-contaminated elective surgeries labelled allergy to penicillin group antibiotics on electronic patient record (ePR) Exclusion Criteria: multiple antibiotic allergy history of severe cutaneous adverse reactions or other severe non-IgE-mediated hypersensitivity (e.g. haemolytic anaemia, organ dysfunction, serum sickness) due to beta-lactam antibiotics on systemic immunosuppressants pregnancy active or uncontrolled chronic urticaria mentally incompetent for informed consent
Sites / Locations
- Prince of Wales HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
Detailed penicillin allergy evaluation during pre-operative care
Standard pre-operative care
This group will undergo a detailed penicillin allergy evaluation performed by an Infectious Diseases specialist. Patients with negative result in skin test and oral provocation test will have their prior labelled penicillin allergy removed from electronic health record, and an additional entry documenting the negative allergy evaluation will be added. A letter signed by an infectious disease specialist documenting the allergy evaluation results will also be given to patients.
This group will receive standard perioperative care. The choice of antibiotics during the perioperative period will be decided by surgical team.