Effects of Epidural Labor Analgesia With Esketamine on the Incidence of Postpartum Depression in Parturients
Postpartum Depression
About this trial
This is an interventional treatment trial for Postpartum Depression focused on measuring Esketamine, Epidural labor analgesia, Postpartum depression
Eligibility Criteria
Inclusion Criteria: Full-term pregnancy; Antenatal depressive state (EPDS score ≥10 and non-depressive diagnosis by a psychiatrist); Epidural labor analgesia; Signed informed consent. Exclusion Criteria: Pre-existing history of definite psychiatric disorders (depression, schizophrenia, etc.) or communication disorders;Presence of severe preoperative pregnancy complications (e.g., severe preeclampsia, placental implantation, HELLP syndrome, placenta praevia, placenta abruptio);ASA classification ≥ grade III;Contraindications to ketamine/S-ketamine (e.g., intractable, refractory hypertension, severe cardiovascular disease [cardiac function class ≥ III], hyperthyroidism); Refusal to participate in the study.
Sites / Locations
- Women's hospital, school of medicine, Zhejiang universityRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Esketamine Group
Control Group
The epidural analgesic drug mix for labour analgesia is ropivacaine 0.08mg/mL compounded with esketamine 0.3mg/mL.
The epidural analgesic drug mix for labour analgesia is ropivacaine 0.08mg/mL compounded with sufentanil 0.3ug/mL.