Prone Positioning and Abdominal Binding on Lung and Muscle Protection in ARDS Patients During Spontaneous Breathing
Acute Respiratory Distress Syndrome, Mechanical Ventilation Complication, ICU Acquired Weakness
About this trial
This is an interventional supportive care trial for Acute Respiratory Distress Syndrome
Eligibility Criteria
Inclusion Criteria: Adult ARDS patients with moderate-severe ARDS on controlled protective mechanical ventilation for more than 3 days Stable hemodynamics Level of consciousness enough to initiate spontaneous breathing Exclusion Criteria: Unstable hemodynamics Tracheostomy Abnormal level of consciousness Central nervous system injury Esophageal varices Pregnancy Contraindications for installation of electrical impedance tomography or ultrasound assessments
Sites / Locations
- Hospital Clínico Universidad de ChileRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Sham Comparator
Experimental
Experimental
Control Group
Prone Positioning
Abdominal Binding
ARDS patients at spontaneous breathing onset on pressure control partial assisted ventilation in supine position at 45º degrees, performed under standard PEEP according to ARDSNet strategy and individualized PEEP applied in random order.
ARDS patients at spontaneous breathing onset on pressure control partial assisted ventilation in prone position, performed under standard PEEP according to ARDSNet strategy and individualized PEEP applied in random order.
ARDS patients at spontaneous breathing onset on pressure control partial assisted ventilation in supine position at 45º degrees using an abdominal binder with the binder's upper edge below the costal margin to allow rib-cage movement, performed under standard PEEP according to ARDSNet strategy and individualized PEEP applied in random order.