A Study to Compare Iberdomide Maintenance Versus Lenalidomide Maintenance Therapy Following Autologous Stem Cell Transplant in Participants With Newly Diagnosed Multiple Myeloma
Multiple Myeloma
About this trial
This is an interventional treatment trial for Multiple Myeloma focused on measuring Multiple Myeloma, Iberdomide, CC-220, Lenalidomide, MM, NDMM, Maintenance, Autologous stem cell transplant, ASCTm
Eligibility Criteria
Inclusion Criteria Confirmed diagnosis of symptomatic multiple myeloma (MM) Eastern Cooperative Oncology Group performance status (ECOG) score of 0, 1, or 2 Received 3 to 6 cycles of an induction therapy that includes a proteasome inhibitor (PI) and immunomodulatory (IMiD) [eg, bortezomib thalidomide and dexamethasone (VTd), lenalidomide, bortezomib and dexamethasone (RVd)] with or without a CD38 monoclonal antibody, or Velcade® (bortezomib), cyclophosphamide, dexamethasone (VCd), and followed by a single or tandem autologous stem cell transplantation (ASCT). Post-stem cell transplant consolidation is permitted Participants within 12 months from initiation of induction therapy who achieved at least a partial response (PR) after autologous stem cell transplantation (ASCT) with or without consolidation, according to International Myeloma Working Group (IMWG 2016) criteria Exclusion Criteria Progressive disease or clinical relapse (as defined by IMWG response criteria) following ASCT with or without consolidation or is not responsive to primary therapy Smoldering myeloma, solitary plasmacytoma or nonsecretory myeloma Known central nervous system/meningeal involvement of MM Prior history of malignancies, other than MM, unless the participant has been free of the disease for ≥ 5 years Other protocol-defined inclusion/exclusion criteria apply
Sites / Locations
- University of California Irvine Medical Center (UCIMC) - Chao Family Comprehensive Cancer Center
- Rocky Mountain Cancer CentersRecruiting
- Poudre Valley Health Care
- Mayo Clinic Florida
- Woodlands Medical Specialists - Pensacola
- H. Lee Moffitt Cancer Center & Research Institute
- Cleveland ClinicRecruiting
- University Cancer Blood CtrRecruiting
- The Winship Cancer Institute of Emory University
- Augusta University - Georgia Cancer Center
- The University of Chicago Medical Center - Duchossois Center for Advanced Medicine
- University of Kansas Cancer Center - The Richard and Annette Bloch Cancer Care Pavilion
- Maryland Oncology Hematology, PA- ClintonRecruiting
- UMass Memorial Medical Center
- University of Michigan - Rogel Cancer Center
- Henry Ford Health System - The Henry Ford Cancer Institute (HFCI) - Detroit
- St. John Hospital and Medical Center - Van Elslander Cancer Center
- Mayo Clinic - Transplant Center - Rochester
- Hattiesburg Clinic - Hematology & OncologyRecruiting
- Midwest Oncology Associates - Kansas CityRecruiting
- Dartmouth-Hitchcock Medical Center (DHMC)
- Morristown Medical Center
- Rutgers Cancer Institute of New Jersey
- NYU Langone Health
- Memorial Sloan-Kettering Cancer Center
- Columbia University Medical Center - Herbert Irving Pavilion Location
- Clinical Research AllianceRecruiting
- Novant Health Cancer Institute - Elizabeth
- Duke University Hospital
- Oncology Hematology Care, Inc. - Cincinnati - Galbraith RdRecruiting
- Cleveland Clinic
- Toledo Clinic Cancer CentersRecruiting
- Willamette Valley Cancer InstituteRecruiting
- Thomas Jefferson University HospitalRecruiting
- Fox Chase Cancer Center - Jeanes Campus
- University of Pittsburgh - Hillman Cancer Center
- Cancer Care Associates of York
- Tennessee Oncology - Chattanooga Oncology & Hematology Associates
- Tennessee OncologyRecruiting
- Texas Oncology - Baylor Charles A. Sammons Cancer CenterRecruiting
- UT Southwestern-Harold C. Simmons Cancer Center
- The University Of Texas MD Anderson Cancer Center
- University of Wisconsin Hospital and Clinics
- Froedtert & Medical College of Wisconsin - Froedtert Hospital - Clinical Cancer Center
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Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Experimental
Active Comparator
Arm A1: Iberdomide Dose 1
Arm A2: Iberdomide Dose 2
Arm A3: Iberdomide Dose 3
Arm B: Lenalidomide