An Effectiveness and Safety 6 Months Study of 3 Injections One Week Apart of SYNOLIS VA 40/80 in the Treatment of Symptomatic Knee Osteoarthritis

Inclusion Criteria: Patient between 35 and 75 years old Patients with knee osteoarthritis. The diagnosis is based on the following American College of Rheumatology (ACR) classification: Knee pain Positive radiography (presence of osteophytes) Morning stiffness < 30 min and/or crepitus while walking Symptoms related to knee osteoarthritis for at least 6 months Treatment failure (i.e. ineffective response) with analgesics and/or NSAIDs or intolerance to NSAIDs or low-grade opioids Kellgren-Lawrence radiographic stage: I - III (pre-inclusion radiography) VAS pain index score ≥ 40 mm (VAS 0-100 mm) on the knee to be treated Contralateral knee pain < 10 mm (VAS) compared to treated knee Patient signed inform consent form Exclusion Criteria: Inability to understand the study or language used to be informed/sign the consent Participation in another clinical trial within 4 weeks prior to the start of the trial, and commitment to non-participation within 4 weeks following the end of the trial Intraarticular injection of hyaluronic acid in target knee within the 6 months prior to inclusion Patient who has received an intra-articular (IA) or intra-muscular (IM) steroid injection within the 3 months prior to inclusion or has taken oral corticosteroids within the month prior to inclusion Joint, bone, ligament, or any local or loco-regional surgery of the leg involved, arthroscopic operation on the target knee within the 3 months prior to inclusion Any recent trauma to the leg involved, including a sprain, dislocation within the 3 months prior to inclusion Rheumatoid arthritis, joint condition or any other inflammation and arthritis Lupus Dermatological disorder or any epidermal conditions that prevent an intraarticular injection Visible remarkable joint effusion of the target knee during physical examination evidenced by a protuberance or positive ballottement of the patella Evidence of a subchondral fracture, meniscal lesion, presence of bone or cartilage fragments, horizontal meniscal lesion tear (FLAP) in the target knee Osteonecrosis (1 or both knees) Daily dosage > 101 mg of acetylsalicylic acid as part of cardiovascular preventive treatment (antithrombotic). If dose < 101 mg, must be maintained during the study Known intolerance/hypersensitivity/allergy to any of the components in either product, SYNOLIS VA Fibromyalgia Patient of childbearing potential, pregnant or breast-feeding known at inclusion or in the planning phase during the study unless willing to use contraceptives through the whole duration of the study Excessive and repeated consumption of alcohol or illicit substances Any medical condition that may interfere with the proper conduct of the study (including any surgery or hospitalisation)