Remote Ischemic Preconditioning in Septic Patients (RIPC-ICU)
Critically Ill, Acute Kidney Injury, Sepsis
About this trial
This is an interventional supportive care trial for Critically Ill
Eligibility Criteria
Inclusion Criteria: Adult patients (age ≥18 years) Critically ill patients with sepsis < 12 hours Invasive ventilation for at least 24 hours (propofol-free-sedation) and/or vasopressor therapy Unrestricted intensive care for at least 72 hours Written informed consent Exclusion Criteria: Pre-existing AKI (Glomerulo-)nephritis, interstitial nephritis, vasculitis Chronic kidney disease with estimated glomerular filtration rate (eGFR) < 30 ml/min/1.73m² Chronic dialysis dependency Kidney transplant in the last 12 months Oral antidiabetics, sulfonamides or nicorandil Pregnancy or breastfeeding Do-not-reanimate order Participation in another interventional trial involving kidney outcomes within the last 3 months Dependency on the investigator or center
Sites / Locations
- University Hospital Münster; Department of Anesthesiology, Intensive Care Medicine and Pain MedicineRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Sham Comparator
Intervention Group
Control Group
Remote ischemic preconditioning (RIPC) Three Cycles of 5-min upper limb ischemia. If there is no response this will be followed by 2 cycles of 10-min upper-limb ischemia.
Three cycles of 5- min upper limb sham ischemia.