Randomized, Double-blind, Placebo-controlled, Crossover Study of Atrasentan in Subjects With IgA Nephropathy (ASSIST)

Inclusion Criteria: Subjects aged 18 and older at the time of signing the informed consent form (ICF) prior to initiation of any study specific activities/procedures. Biopsy-proven IgA nephropathy. Receiving a maximally tolerated and stable dose of RAS inhibitor therapy (ACEi or ARB) for at least 12 weeks prior to screening. Investigator discretion should be used in determining maximally tolerated and stable dose. eGFR of at least 30 mL/min/1.73 m2 at screening based on the CKD-EPI equation. Willing to agree to highly effective forms of contraception, as specified in the protocol, throughout the study and for up to 1 month afterward. In WOCBP, use of hormonal contraceptive agents must have been started at least 1 month prior to baseline. Willing and able to provide informed consent and comply with all study requirements. Inclusion Criteria for SGLT2i stable subjects Receiving a stable dose of an SGLT2i for at least 8 weeks prior to screening Must have a 24-hour urine protein of >0.5 grams/day. Inclusion Criteria for Run-In Subjects Must have a 24-hour total urine protein of >0.85 grams/day at screening Willing to participate in an 8-week run-in period with an SGLT2i (per Investigator choice) Additional Inclusion Criteria for Run-in Subjects at the end of Run-In Must have completed the 8-week run-in period on a stable and well tolerated dose of an SGLT2i Must have a 24-hour total urine protein of >0.5 grams/day confirmed at the Week -1 Visit Must have an eGFR of ≥ 30 mL/min/1.73 m2 based on the CKD-EPI equation at the Week -1 Visit Receiving treatment with SGLT2i at a stable dose for at least 8 weeks prior to screening. Exclusion Criteria: Current diagnosis with another chronic kidney disease, including diabetic kidney disease. History of kidney transplantation or other organ transplantation. Use of systemic immunosuppressant medications, such as steroids, for more than 2 weeks in the past 3 months. Blood pressure above 150 mmHg systolic or 95 mmHg diastolic as evaluated by the Investigator. Known history of heart failure or a previous hospital admission for fluid overload. Clinically significant history of liver disease as assessed by the Investigator. Hemoglobin below 9 g/dL as measured by the Investigator or prior history of blood transfusion for anemia within the past 3 months. Malignancy within the past 5 years. Exceptions to this criteria include nonmelanoma skin cancer and curatively treated cervical carcinoma in situ. For women, pregnancy, breast feeding, or intent to become pregnant during the study. and at least 1 month afterward. For men, intent to father a child or donate sperm during the study. Have received any investigational agent or approved treatment for IgAN (other than a RAS inhibitor) including SGLT2i (except for subjects in the SGLT2i stable stratum) within 1 month (or 5 half-lives of the agent, whichever is longer) prior to Screening. If the investigational agent is a cytotoxic or immunosuppressive agent then this washout period is 6 months.