Biological Responses Affecting Early-stage Dental Implant Placement in Patients With History of Periodontitis
Periodontitis, Peri-implant Mucositis, Peri-Implantitis
About this trial
This is an interventional basic science trial for Periodontitis focused on measuring dental implant, history of periodontitis, matrix metalloproteinase (MMP)-8, histological analysis, next generation sequencing, dental plaque, gingival crevicular fluids, peri-implant sulcular fluids, peri-implant soft tissue, proteomic analysis
Eligibility Criteria
Inclusion Criteria: Specific inclusion criteria for test group: History of periodontitis but currently stable Must have successfully completed active periodontal treatment at least 4 months prior to the commencement of study Specific inclusion criteria for control group: No history of periodontitis, with minimal age-related radiographic bone loss Reason for losing the tooth/teeth was not due to periodontal problem General inclusion criteria: Medically healthy Aged between 30 to 65 years old Non-smoker, or quit smoking at least 12 months before study commencement Good oral hygiene (full mouth plaque score (FMPS)<20%, full mouth bleeding score (FMBS)<15%) Indicated for a single implant placement in the posterior region, with adjacent and contralateral natural tooth Intact inter-cuspal position Exclusion Criteria: Previous history of dental implant placement Currently pregnant or intend to be pregnant, and/or lactating mothers Taking long-term medicines which may affect gingival tissue and oral microbiome, e.g. antibiotics, anticoagulants, anticonvulsants, immunosuppressants and calcium channel blockers.
Sites / Locations
- Faculty of Dentistry, University of Malaya
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Active Comparator
Active Comparator
Group T-A
Group T-B
Group C-A
Group C-B
7 patients with history of periodontitis
7 patients with history of periodontitis
7 patients without history of periodontitis
8 patients without history of periodontitis