Cilostazol Dexborneol Versus Placebo for Microcirculation Dysfunction After Reperfusion Therapy in Patients With Acute Ischemic Stroke With Large Vessel Occlusion (CRYSTAL)

Inclusion criteria: 35 years old ≤ Age ≤ 80 years old Patients with acute ischemic stroke was diagnosed within 24 hours of onset (time from onset to completion of reperfusion therapy) Patients with first stroke or prior to stroke onset (mRS score 0-1) Patients with acute large vessel occlusion (LVO) confirmed by imaging, including the responsible vessel was located in the intracranial internal carotid artery, the T-shaped branch, the M1/M2 segment of the middle cerebral artery, or the A1/A2 segment of the anterior cerebral artery ASPECTS score ≥ 6 6<NIHSS score ≤ 25 after the onset of this disease Patients who meet the indications for reperfusion therapy, including mechanical thrombectomy, bridging therapy (intravenous r-tPA thrombolytic therapy), and plan to undergo mechanical thrombectomy Patients or his/her legal representatives are able to understand and sign the informed consent Exclusion criteria: Severe consciousness disturbance: NIHSS 1a consciousness level ≥2 points Patients with definite history of intracranial hemorrhage (such as subarachnoid hemorrhage, cerebral hemorrhage, etc.) Patients with intracranial tumor, arteriovenous malformation, or aneurysm Patients with bilateral anterior or posterior circulation ischemic stroke Patients with large vascular occlusion of rare or unknown etiology, such as dissection, vasculitis, etc. Patients who have received treatment with dual antiplatelet drugs, tirofiban, warfarin, novel oral anticoagulant, argatroban, snake venom, defibrase, lumbrokinase and other defibrase therapy after the onset of disease Patients with severe hepatic insufficiency or renal insufficiency and received dialysis for various reasons before randomization (severe hepatic insufficiency is defined as ALT > 3 × ULN or AST >3 × ULN; severe renal insufficiency is defined as serum creatinine >3.0 mg/dL (265.2 μmol/L) or creatinine clearance < 30 mL/min) Patients with haemorrhagic diathesis (including but not limited to): platelet count < 100 × 109/L; heparin treatment within the last 48 hours; taking oral warfarin; taking novel oral anticoagulant; administration with direct thrombin or Xa factor inhibitors; with hereditary hemorrhagic disorders, such as hemophilia Patients with refractory hypertension that is difficult to be controlled by medication (systolic blood pressure > 180 mmHg or diastolic blood pressure > 110 mmHg) Patients with significant head trauma or stroke within 3 months prior to randomization Patients who have received intracranial or spinal surgery within 3 months prior to randomization Patients with history of major surgery or serious physical trauma within 1 month prior to randomization Patients with hemorrhagic retinopathy Male subjects (or their partners) or female subjects who had planned to have a child during the whole study period and within 3 months after the end of the study period or were unwilling to use one or more non-drug contraceptive methods (e.g., complete abstinence, condoms, ligation, etc.) during the study period Patients with contraindications to known contrast agent or other contrast agents; subjects who are allergic to cilostazol or dexborneol Patients who plan to receive other surgical or intervention therapy within 3 months, which might require discontinuation of the study drugs Patients with advanced disease, leading to life expectancy of < 6 months Patients who have received treatment of investigational drug or device within 3 months Other conditions where it is not suitable for patients to participate in the clinical trial, such as inability to understand and/or follow the study procedures and/or follow-up schedule due to psychiatric disorders or cognitive/emotional disorders, or contraindications to thrombectomy or MRI, etc.