Complex and Simple Appendicitis: REstrictive or Liberal Post-operative Antibiotic eXposure (CASA RELAX) (CASA-RELAX)
Appendicitis
About this trial
This is an interventional treatment trial for Appendicitis focused on measuring appendicitis, appendectomy, antibiotic duration
Eligibility Criteria
Inclusion Criteria: Age ≥ 18 years Planned appendectomy (laparoscopic or open) Willing and able to provide informed consent Working telephone number or reliable method to contact patient after hospital discharge Exclusion Criteria: Unable to consent Pregnant Women Prisoners Immunocompromised as determined by clinical team, or patients actively receiving steroids, chemotherapy, or immunosuppressing medications (for example tacrolimus), or patients with active hematologic malignancy affecting the immune system, leukopenia, or end-stage AIDS Heart failure Allergy to bupivacaine Unlikely to comply with treatment or follow-up Inpatient consultation for appendicitis Clinically suspected of sepsis based on Sepsis-3 definition Current use of antibiotics for other indications Type 1 Diabetes or uncontrolled hyperglycemia Surgeon preference Patient preference Research team unavailable
Sites / Locations
- Jewish Hospital ULRecruiting
- University of Louisville HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Arm 7
Arm 8
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Active Comparator
under 65 years simple appendicitis restricted duration
Under 65 simple appendicitis liberal duration
Under 65 complex appendicitis restricted duration
Under 65 complex appendicitis liberal duration
Over 65 simple appendicitis restricted antibiotic duration
Over 65 simple appendicitis liberal antibiotic duration
Over 65 complex appendicitis restricted antibiotic duration
Over 65 appendicitis liberal antibiotic duration
simple appendicitis restricted duration of no postop antibiotics
simple appendicitis liberal duration of 24 hours postop antibiotics
complex appendicitis restricted duration of 24 hours postop antibiotics
complex appendicitis liberal duration of 4 days of postop antibiotics
see above for under 65
see above for under 65
see above for under 65
see above for under 65