Acute Alcohol Response In Bipolar Disorder: a Longitudinal Alcohol Administration/fMRI Study (Long_BACS)
Bipolar Disorder, Alcohol Drinking, Alcohol Use Disorder
About this trial
This is an interventional prevention trial for Bipolar Disorder
Eligibility Criteria
Inclusion Criteria: Inclusion criteria for all participants: between 21 and 26 years of age having consumed at least 4 (men) or 3 (women) drinks on a single occasion over the last year euthymic at the time of study Inclusion criteria for bipolar disorder participants: - Meeting Diagnostic and Statistical Manual-5 Research Version (DSM-V-RV) diagnostic criteria for bipolar disorder, confirmed by structured interview Exclusion Criteria: For all subjects exclusion criteria include: history of significant medical illness, particularly if possible changes in cerebral tissue neurologic abnormality including significant head trauma (loss of consciousness of ≥5-min) full Scale intelligence quotient (IQ) <85 contraindication to MRI scanning positive pregnancy test current cannabis use disorder>moderate history of severe AUDs scores > 15 on the alcohol Use Disorders Identification Test (AUDIT; part of phone screen) ever being in an abstinence-oriented treatment program for alcohol use reporting wanting to quit drinking but not being able to any medical, religious, or other reasons for not drinking alcohol history of heart attack, heart trouble, high blood pressure, diabetes, or liver disease an adverse reaction to alcoholic beverages reporting never consuming 4 (men) or 3 (women) or more drinks on a single occasion over the last year unwillingness to have a friend or family member drive them home after the alcohol administration sessions a past year substance use disorder (other than alcohol, cannabis, or nicotine) Additional exclusion criteria for bipolar disorder participants: - not taking medications for greater than or equal to 4 weeks (i.e. participants must be stable on medications) Additional exclusion criteria for healthy comparison subjects also include: any prior psychiatric hospitalizations lifetime history of a neurodevelopmental disorder, affective disorder, psychotic disorder, eating disorder greater than 1 month of lifetime psychotropic medication.
Sites / Locations
- University of Texas at AustinRecruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Placebo Comparator
Alcohol
Placebo
Participants will be provided alcohol during study visits and changes in behavior/neural activity after consuming alcohol will be examined.
placebo beverage condition