Dasatinib Plus Quercetin for Accelerated Aging in Mental Disorders
Schizophrenia, Treatment Resistant Depression, Aging, Premature
About this trial
This is an interventional prevention trial for Schizophrenia focused on measuring Schizophrenia, Treatment Resistant Depression, Aging, Premature, Older Adults
Eligibility Criteria
Inclusion Criteria: Either major depression, which is treatment-resistant (currently depressed despite at least 2 adequate trials of antidepressants in this or the previous episode), or schizophrenia/schizoaffective disorder. Age 50+ (60+ for depression). Three conditions associated with aging (e.g., hypertension/diabetes/metabolic syndrome, cardiac disease, lung disease other than asthma, cancer with adult-onset, arthritis, and inflammatory diseases typically seen in aging). No history of dementia by patient report. Already taking an adequate dose of medication for schizophrenia/schizoaffective disorder or depression. Exclusion Criteria: Contraindications for dasatinib or quercetin Active SI such that participant could not be safely managed in an outpatient clinical trial. Taking medications that are strong CPY3A4 inhibitors or strong inducers, or that induce senescence (e.g., alkylating agents, anthracyclines, platins/other chemotherapy), or everolimus and topotecan (which have interactions with quercetin). All medications and medical conditions will be reviewed by physician study investigators to determine whether the medication or condition, in the opinion of the investigators, makes the participant inappropriate for the study. Examples of such potential excluding conditions: Active inflammatory, infectious, or malignant disease; sensory deficits that would interfere with assessments; recent heart attack or stroke; severe bleeding disorder; uncontrolled hypertension or diabetes mellitus; active liver disease or cirrhosis; current use of systemic steroids, quinolone antibiotics, hydroxychloroquine or chloroquine.
Sites / Locations
- Washington University School of MedicineRecruiting
Arms of the Study
Arm 1
Experimental
Dasatinib + quercetin
open label dasatinib plus quercetin combined as a drug therapy