Adjunctive Esketamine for Analgesia in Mechanically Ventilated Septic Shock Patients

Inclusion Criteria: Age ≥ 18; A patient diagnosed with septic shock; It needs to be treated with analgesics, sedatives, and vasopressors for a period of not less than 48 hours; Mechanical ventilation by the ventilator is needed; Obtain the informed consent of the human subjects or their legal representatives; Exclusion Criteria: Pregnant patient The patient had acute coronary syndrome, NYHA grade IV, or refractory heart failure; Any other condition that may seriously interfere with the collection of research data, such as loss of hearing or vision; any allergic reaction to any of the research drugs; The clinician determines that a patient who is unlikely to be separated from mechanical ventilation, such as a disease/injury that primarily affects the neuromuscular function of the respirator and an apparently irreversible disease requiring long-term ventilation support (such as high spinal cord injury); The researcher judged that it was not suitable to participate in the study;