Comparison of Ciprofol-based and Propofol-based Total Intravenous Anesthesia on Postoperative Quality of Recovery

Comparison of Ciprofol-based and Propofol-based Total Intravenous Anesthesia on Postoperative Quality of Recovery

Comparison of Ciprofol-based and Propofol-based Total Intravenous Anesthesia on Postoperative Quality of Recovery in Elderly Patients Undergoing Gastrointestinal Surgery

Ciprofol is a novel 2,6-disubstituted phenol derivatives and is proved have much higher potency and tighter binding toward ɣ-aminobutyric acid type A (GABAA) receptor while maintaining a fast on-set and recovery time compared to propofol. Except lower incidence of hypotension and respiratory depression, it has no injection pain and infusion syndrome compared with propofol. There is no study to investigate overall postoperative functional recovery in patients receiving total intravenous anesthesia (TIVA) using ciprofol yet. However, according to study, early quality of recovery according to QoR-15 score is associated with one-month postoperative complications after elective surgery. Therefore, the purpose of this study is to determine whether there is any difference in the quality of postoperative recovery between ciprofol-based and propofol-based TIVA in elderly patients undergoing gastrointestinal surgery. The QoR-15 questionnaire score, pain, nausea/vomiting, and the frequency of complications are evaluated and compared between the two groups.

Anesthetics, Intravenous, Postoperative Complications, Hypnotics and Sedatives, Postoperative Recovery

participants were anesthetized and were unaware of the grouping. Care providers did not know the grouping. Specific investigators who did the intervention were aware of the grouping. The outcome assessors and the data analyzers did not know the grouping.

Ciprofol group will be started and maintained total intravenous anesthesia with ciprofol and remifentanil

Propofol group will be started and maintained total intravenous anesthesia with propofol and remifentanil

Quality of life will be evaluated using Quality of Recovery(QoR)-15 questionnaire score at postoperative day 1(minimum value: 0, maximum value: 150, the higher the score, the better the result)

Quality of life will be evaluated using Quality of Recovery(QoR)-15 questionnaire score at postoperative day 2 (minimum value: 0, maximum value: 150, the higher the score, the better the result)

Record the mean arterial pressure (MAP) at different points, including before induction, after induction, immediately after intubation, at the beginning of surgery, at the end of anesthesia, immediately after extubation, and before leaving the room

From stopping ciprofol or propofol infusion to awake and withdrawal of tracheal tube, approximately 30 minutes

Monitored by the sedation scale called Sedation-Agitation Scale (SAS). SAS is a medical scale used to measure the agitation or sedation level of a person.The score ranges from 1 to 7

postoperative pain score measured by 11-point VAS (Visual Analogue Scale) score (minimum : 0, maximum : 10, the lower the score, the lesser pain)

Postoperative nausea and vomiting will be evaluated by PONV (Post Operative Nausea And Vomiting) score (no : 0, vomit: 4)

Inclusion Criteria: Patients undergoing elective gastrointestinal surgery under endotracheal intubation and general anesthesia American Society of Anesthesiologists (ASA) classification: I to III; Age ≥ 60 years, BMI < 30 kg/m2; Unconscious speech audiovisual impairment or unable to cooperate; Informed consent has been signed. Exclusion Criteria: Taking any sedative, opioid, or sleep aid drugs; Psychiatric or neurological disorder; Allergic to ciprofol, propofol or soy, or a family history of malignant hyperthermia; Severe liver and kidney dysfunction; Operation duration < 2 hours; Plan to the intensive care unit with tracheal catheter; Have participated in this study or other clinical studies.

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