Impact of Susceptibility to Placebo on the Effect of Transcranial Direct Current Stimulation (tDCS) in Fibromyalgia (FIBROTEC)
Fibromyalgia
About this trial
This is an interventional treatment trial for Fibromyalgia focused on measuring Fibromyalgia; tDCS; ß-endorphin; placebo effect; pain
Eligibility Criteria
Inclusion Criteria: Women aged 18 to 65 years; who can read and write, with a confirmed diagnosis of FM according to the American College of Rheumatology criteria (2010-2016). Pain score equal to or greater than six on the Numerical Pain Scale (NPS 0-10) on most days of the last 3 months. Exclusion Criteria: Residing outside the greater Porto Alegre area and pregnancy. Contraindications to TMS and tDCS: metallic implant in the brain; medical devices implanted in the brain, cardiac pacemakers; cochlear implant; history of alcohol or drug abuse in the last 6 months; neurological pathologies; hx of head trauma or neurosurgery; decompensated systemic diseases and chronic inflammatory diseases (lupus, rheumatoid arthritis, Reiter's syndrome); uncompensated hypothyroidism; personal history of cancer, past or undergoing treatment.
Sites / Locations
- Hospital de Clinicas de Porto Alegre
Arms of the Study
Arm 1
Arm 2
Placebo Comparator
Active Comparator
Respondres placebo effect
No respondres placebo effect
Intervention: 'Transcranial Direct Current Stimulation - tDCS The patients will receive tDCS stimulation treatment prefrontal cortex dorso lateral According to 10-20 EEG system, anode will be placed at left F3 and cathode at contralateral F4. Placebo stimulation uses a 2 milliamperes current during in the first minutes, in the 10 min and in 19 minutes.
Intervention: 'Transcranial Direct Current Stimulation - tDCS The patients will receive tDCS stimulation treatment prefrontal cortex dorso lateral According to 10-20 EEG system, anode will be placed at left F3 and cathode at contralateral F4. Active stimulation uses a 2 milliamperes current during 20 minutes.