CAT BITE Antibiotic Prophylaxis for the Hand/Forearm (CATBITE) (CATBITE)
Cat Bite, Hand Injuries, Arm Injury
About this trial
This is an interventional prevention trial for Cat Bite
Eligibility Criteria
Inclusion Criteria: Patients greater or equal to 18 years of age. Bitten by a cat. Location of bite is the hand and/or forearm (distal to elbow). Presenting <24 hours following a cat bite to the hand/forearm. English speaking Exclusion Criteria: Patients who present with active local or systemic infections Purulent drainage from the cat bite Redness AND swelling at the location of the cat bite Having a fever >100.4° F or >38° C)-Received antibiotics within the past 30 days Received antibiotics within the past 30 days Patients unwilling to take study medication Patients unwilling to attend scheduled follow-up evaluations or complete study forms Pregnant Women Type I hypersensitivity reaction to any of the study interventions Immunocompromised patients (primary and secondary immunodeficiencies) Primary Autoimmune Lymphoproliferative Syndrome (ALPS) Autoimmune Polyglandular Syndrome type 1 (APS-1) B-cell Expansion with Nuclear factor kappa-light-chain-enhancer of activated B cells and T-cell Anergy (BENTA) Disease Caspase Eight Deficiency State (CEDS) Caspase Recruitment Domain Family Member 9 (CARD9) Deficiency and Other Syndromes of Susceptibility to Candidiasis Cartilage-hair hypoplasia Chédiak-Higashi syndrome Chronic Granulomatous Disease (CGD) Common Variable Immunodeficiency (CVID) Complement Deficiencies Congenital Neutropenia Syndromes Cytotoxic T-Lymphocyte Associated Protein 4 (CTLA4) Deficiency Cyclic neutropenia DiGeorge syndrome Dedicator Of Cytokinesis 8 (DOCK8) Deficiency GATA-binding protein 2 (GATA2) Deficiency Glycosylation Disorders with Immunodeficiency Hyper-Immunoglobulin E Syndromes (HIES) Hyper-Immunoglobulin M Syndromes Interferon Gamma, Interleukin 12 and Interleukin 23 Deficiencies Leukocyte Adhesion Deficiency (LAD) Types 1 and 2 Lipopolysaccharide Responsive Beige-Like Anchor Protein (LRBA) Deficiency Phosphatidylinositol 3-kinase (PI3-Kinase) Disease Phospholipase C gamma 2 (PLCG2) associated Antibody Deficiency and Immune Dysregulation (PLAID) Severe Combined Immunodeficiency (SCID) Selective Immunoglobulin A (IgA) deficiency Signal transducer and activator of transcription 3 (STAT3) Dominant-Negative Disease STAT3 Gain-of-Function Disease Warts, Hypogammaglobulinemia, Infections, and Myelokathexis (WHIM) Syndrome Wiskott-Aldrich Syndrome (WAS) X-Linked Agammaglobulinemia (XLA) X-Linked Lymphoproliferative Disease (XLP) X-linked magnesium transporter 1 (MAGT1) deficiency with increased susceptibility to Epstein-Barr virus (EBV) infection and N-linked glycosylation defect (XMEN) Disease Zeta-associated protein 70 (ZAP-70) deficiency Secondary Malnutrition Uncontrolled Diabetes mellitus Chronic uremia Genetic syndromes: trisomy 21 Immunomodulatory, immunosuppressive drug therapy: corticosteroids, calcineurin inhibitors, cytotoxic agents Systemic lupus erythematosus Malignancy Active radiation therapy Bone marrow ablation Infectious diseases: human immunodeficiency virus (HIV) infection, Hepatitis Additional Primary and secondary immunodeficiencies can be found at the following link. https://www.merckmanuals.com/professional/immunology-allergic-disorders/immunodeficiency-disorders/overview-of-immunodeficiency-disorders
Sites / Locations
- University of MissouriRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Placebo Comparator
Active Comparator
Active Comparator
Placebo (microcrystalline cellulose)
Antibiotic x 1 day
Antibiotic x 5 days
Placebo capsules by mouth twice daily x 5 days (5 days of placebo microcrystalline cellulose capsules)
Amoxicillin-clavulanate 875-125mg capsules by mouth twice daily x 1 day (4 days of placebo capsules) -Penicillin allergy: ciprofloxacin 500mg by mouth twice daily + clindamycin 300mg by mouth three times daily x 1 day
Amoxicillin-clavulanate 875-125mg capsules by mouth twice daily x 5 days (0 days of placebo capsules) -Penicillin allergy: ciprofloxacin 500mg by mouth twice daily + clindamycin 300mg by mouth three times daily x 5 days