buRst-supprESsion TO Stop Refractory Status Epilepticus Post-cardiac Arrest (RESTORE)
Hypoxia-Ischemia, Brain, Heart Arrest, Status Epilepticus
About this trial
This is an interventional treatment trial for Hypoxia-Ischemia, Brain
Eligibility Criteria
Inclusion Criteria: Age ≥18 years old Non-traumatic, out-of-hospital cardiac arrest Comatose on admission - defined as not following commands Return of spontaneous circulation (ROSC) within less than 45 minutes Admission to the intensive care unit Diagnosis of post-cardiac arrest refractory status epilepticus confirmed with continuous EEG monitoring within 7 days from ROSC Exclusion Criteria: Acute cerebral hemorrhage or infarction Pregnancy Prisoners
Sites / Locations
- Zuckerberg San Francisco General HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Other
Other
Burst Suppression EEG Target
Seizure Suppression EEG Target
Anesthetic will be titrated to achieve burst suppression on continuous EEG (50-99% attenuation/suppression) for 24 hours.
Anesthetic will be titrated to achieve seizure suppression on continuous EEG for 24 hours.