Xylitol Use for Decolonization of C. Difficile in Patients With IBD
Inflammatory Bowel Diseases, Clostridioides Difficile Infection
About this trial
This is an interventional treatment trial for Inflammatory Bowel Diseases focused on measuring Crohn's Disease, Ulcerative colitis
Eligibility Criteria
Inclusion Criteria: Signed informed consent. Male or female ≥ 18 years of age IBD diagnosis (CD, UC or indeterminant Colitis will be permitted) Presenting for outpatient colonoscopy for any indication Exclusion Criteria: Unable to provide consent Patients with previous colectomy, ostomy, J-pouch, or previous colon surgery (excluding appendectomy) Unable to complete study procedures Chronic use of antibiotics Inability or unwillingness to swallow capsules Allergy to xylitol or sucralose
Sites / Locations
- Brigham and Women's Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Xylitol
Sucralose
Patients in this arm will be receiving 7.5g/day of Xylitol over a 4 week period.
Patients in this arm will be receiving 250mg/day of sucralose over a 4 week period.