Circulating Tumor DNA as Surgical Biomarker in Patients With PancrEatic Adenocarcinoma for Statement of Resectability (CASPER)

Inclusion Criteria: Patients with PDAC with indication to surgical resection, including those undergoing upfront surgery or surgery following induction treatment. Non resectable patient defined as a patient with surgical indication at standard preoperative clinical, biological and morphological evaluation, but eventually not resected because of advanced disease or contraindications revealed during surgical exploration will be excluded Non-metastatic status confirmed by an abdomen CT-scan (as our routine clinical practice). Patients able to give a specific informed consent. Age ≥ 18 years. Exclusion Criteria: Non resectable patient defined as a patient with surgical indication at standard preoperative clinical, biological and morphological evaluation, but eventually not resected because of advanced disease or contraindications revealed during surgical exploration will be excluded (drop-out) Non-controlled congestive heart failure. Non-treated angina. Recent myocardial infarction (in the previous year). Non-controlled AHT (SBP >160 mm or DBP > 100 mm, despite optimal drug treatment). Long QT. Major non-controlled infection. Severe liver failure. Age < 18 years. Informed consent not signed. Pregnant or breastfeeding women and women of child-bearing age not using effective means of contraception.