The Effect of Theta-burst Stimulation on Serum BDNF
Gambling Disorder
About this trial
This is an interventional treatment trial for Gambling Disorder focused on measuring Brain-Derived Neurotrophic Factor, Theta Burst Stimulation
Eligibility Criteria
Inclusion Criteria: age between 20 and 65 years; fulfilling the Diagnostic and Statistical Manual version 5 (DSM-5) criteria of Major depressive disorder assessed by the Structured Clinical Interview Exclusion Criteria: Inability to provide informed consent or comprehend the study procedure; A major psychiatric illness including schizophrenia spectrum disorder, bipolar spectrum disorder, and major depressive disorder with psychotic features. A current DSM-5 diagnosis of substance use disorder except nicotine use disorder or the use of one to two low-potency benzodiazepine tablets for sleep impairment; Have known preexisting noise-induced hearing loss, concurrent treatment with ototoxic medications, or with cochlear implants. Unstable medical illness, including malignancy, uncontrolled diabetes mellitus, unstable cardiac disease or recent myocardial infarction, or cerebrovascular or cardiovascular risk factors that require intensive medical management On medications known to lower seizure threshold (e.g., TCA, bupropion, clozapine) Implants controlled by physiological signals, including pacemaker, implantable cardioverter defibrillator, cochlear implant. Metallic objects in the head, including stenting, suture. Elevated risk of seizure due to traumatic brain history, seizure history, and head trauma, intracranial lesion, and alcohol or benzodiazepines withdrawal syndrome, stimulant intoxication.
Sites / Locations
- Taipei City HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Sham Comparator
Active arm
Sham arm
Prolonged iTBS sessions are scheduled daily in a 5-day sequence for 10 sessions over two weeks
Sham stimulation sessions are scheduled daily in a 5-day sequence for 10 sessions over two weeks