Efficacy of Glutamine in Management of Radiation Mucositis
Radiation-Induced Mucositis
About this trial
This is an interventional supportive care trial for Radiation-Induced Mucositis focused on measuring glutamine, Oral Mucositis, Salivary TGF b1
Eligibility Criteria
Inclusion Criteria: a) Patients with a confirmed histologic diagnosis of H&N malignancy who are referred to non-palliative radiotherapy in the oral cavity. b) Patient who is receiving radiation therapy with intensity modified radiotherapy IMRT or 3D techniques. c) Patients received 50-70 Gy of total radiation at the rate of 2 Gy/fraction daily and 5 fractions/week. d) Patient who received concurrent chemotherapy with radiotherapy e) Presence of Oral Mucositis f) Age 20-70 years old g) Willing to participate in the study h) Able to complete the study assessments Exclusion Criteria: a) Have a confirmed or medically treated diabetes mellitus25 b) Radiotherapy within the last 6 months prior to this study c) Vulnerable patients
Sites / Locations
- ain shams UniversityRecruiting
- Fatma E.SayedRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
Group I (Test group):
Group II (Control group)
Will include twenty patients receiving Glutamine oral suspension (5 grams of glutamine and 5 g maltodextrin dissolved in cold water) 30 min before a meal, 3 times per day through swish and swallow technique25 throughout the radiotherapy period.
Included twenty patients receiving maltodextrin oral suspension (5 g maltodextrin dissolved in cold water) 30 min before a meal, 3 times per day through swish and swallow technique throughout the radiotherapy period along with general measures as well as analgesic drugs according to the WHO scale.