Pharmacokinetics of ZSP1273 in Participants With Hepatic Impairment
Hepatic Impairment, Pharmacokinetics

About this trial
This is an interventional basic science trial for Hepatic Impairment
Eligibility Criteria
Inclusion Criteria: Participant must be ≥ 18 to ≤ 68 years, at the time of signing the informed consent. BMI ≥ 18 kg/m2 up to ≤ 32 kg/m2. Participates (including partners) must use reliable methods of contraception during the study and until 3 months following the last dose of investigational product. Signature of a dated Informed Consent Form (ICF) indicating that the participates has been informed of all the relevant aspects(including adverse events) of the trial prior to enrollment. Participants with hepatic impairment only: Supporting documents confirming that the participant has liver cirrhosis with hepatic impairment must be available. Unless otherwise stated, participants must have been on stable doses and regimens of the concomitant medication for at least 4 weeks before screening, or treatment-naïve participants Exclusion Criteria: Participates with an allergic disposition (multiple drug and food allergies) or who, as determined by the investigator, are likely to be allergic to the investigational drug product or any component of the investigational drug product. QTcF (male) > 470ms,QTcF (female) > 480ms Participates with serious infections, trauma, gastrointestinal surgery or other major surgical procedures within 4 weeks Participates who donated blood or bleeding profusely (> 400 mL) in the 3 months. Pregnant or lactating women, or women of childbearing age with a positive pregnancy test Smoking averaged more than 10 cigarettes per day in the 3 months prior to screening Participants with Normal Hepatic Function Only: Any history of hepatic impairment, or potential presence of liver function impairment by physical examination and laboratory examination at screening. Participants with Hepatic Impairment Only: Any history of clinically serious illness or disease or condition except for primary liver disease that the investigator believes may affect the results of the trial, including but not limited to a history of circulatory, endocrine, nervous, digestive, urinary, respiratoryor hematological, immune, psychiatric, and metabolic disorders. Participates with drug-induced liver injury; history of liver transplantation; cirrhosis in combination with the following complications: including but not limited to liver failure, hepatic encephalopathy, hepatocellular carcinoma, esophageal bleeding from ruptured fundic varices
Sites / Locations
- The First Hospital of Jilin University
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Experimental
Child-Pugh A
Child-Pugh B
Normal hepatic function
8 participants with mild hepatic impairment (Child-Pugh A) will be given 600mg of ZSP1273.
8 participants with moderate hepatic impairment (Child-Pugh B) will be given 600mg of ZSP1273.
8 participants with normal hepatic function will be given 600mg of ZSP1273.